Within this thesis, two ergonomics (i.e. seating comfort and long-distance driving fatigue problems) and two structural bio-mechanics (i.e. femur-fracture fixation and radius-fracture fixation) problems are investigated using musculo-skeletal multi-body dynamics and finite element computational analyses.;Within the seating comfort problem analyzed, a complete-body finite element model is constructed and used to assess the effect of seat geometry and seating posture on the feel of comfort experienced by a seated human.;Within the long-distance driving fatigue problem, musculo-skeletal analysis is employed to assess the extent of fatigue experienced by a driver through the evaluation of level of activity of his/her various muscles.;Within the femur-fracture fixation problem, physiologically realistic loading conditions associated with active daily activities (i.e. cycling) are employed within a finite-element frame work to assess fracture fixation performance and durability of the implant.;Within the radius-fracture fixation problem, the analysis developed within the femur-fracture fixation problem is further related to indicate the effects of other types of loadings (associated with additional daily activities) and improved biological and structural material model are employed.;For all cases studied in the present work, relevant experimental data are used to validate the computational procedure employed. |