| Background. The aim of the Masters of Science in Clinical and Biomedical Investigations is for the candidate to develop the ability to conduct a real-world clinical study.;Aims of this thesis. To describe the problems encountered and the specific solutions identified in conducting a clinical study investigating genotype: phenotype relationships in type 2 diabetes and to derive generalizable principles to assist the candidate and other novice researchers in future research.;Method. The research is presented in typical format with the discussion focusing on an assessment of problems encountered and lessons learned.;Results. Several problems were encountered, particularly an inability to achieve target enrollment, unexpected results that were of debated cause and significance and a small sample size all of which limited the ability to confidently interpret the data.;Conclusion. Adequate sample size is central to confident data analysis and should increase the success of a clinical research study. |
