| Chapter 1: Examples of organocatalytic asymmetric and regioselective non-acyl group transfers to alcohols are reviewed.;Chapter 2: The asymmetric syntheses of L,L- and L,D-di-myo-inositol-1,1'-phosphate is described. Each diastereomer was independently synthesized by the reaction of a chiral nucleophilic peptide catalyst with an inositol-containing chiral phosphoryl chloride to yield the desired diastereomer in each series. Both isomers were shown to exhibit thermoprotective activity of an enzyme at elevated temperature.;Chapter 3: Approaches towards the asymmetric synthesis of a glycosylphosphatidylinositol are discussed. These novel approaches utilize asymmetric phosphorylation to access the inositol portion. |
