| Nanoparticle-based carrier systems have emerged not only as a new method for therapeutics but also as a field of research in biomedical tecnology. Using such systems, we can improve the delivery of molecules into targeted regions of the body and to visualize the delivery process by conjugating imaging modality onto the carrier system. Several features are necessary for a successful carrier: (1) biocompatibility and biodegradability of the nanoparticle support, (2) simple processes for surface chemistry and purification, (3) optimized physicochemical characteristics, (4) high loading efficiency, and (5) capability for large-scale good manufacturing practice. Mesostructured silica materials have several advantageous properties as a carrier system, which include biocompatibility, highly porous framework, and ease of functionalization. In this dissertation, we demonstrate the biomedical applications of mesostructured silica materials in medical imaging, drug delivery, and antimicrobial agents. The synthesis of mesostructured silica nanoparticles that are highly dispersible in aqueous solution and able to deliver anticancer drugs into cancer cells is explained. We present our study on the cellular uptake mechanism and various modifications of the nanoparticles in order to maximize their efficiency as a carrier system. We show the versatility of mesostructured silica materials by integrating multiple functional components on the nanoparticles that can be used for dual-imaging, targeting specific cells, as well as drug delivery. Exploiting the ability to encapsulate metal nanocrystals in the mesostructured silica framework, we extended our studies to micro-organisms and developed antimicrobial system based on the hybrid materials. |
