Analysis Of Prognostic Risk Factors And Survival In 146 Cases Of Double Primary Cancers With Lung Cancer

Objective:To retrospectively analyze the clinical and pathological data of patients with double primary cancers of lung cancer,and to explore the risk factors that affect the prognosis of patients with lung cancer as the first primary cancer and the second primary cancer respectively.Method:From January 2012 to December 2015.146 patients with lung cancer were admitted to Liaoning Cancer Hospital.All patients had two kinds of malignant tumors,one of which was lung cancer.They were divided into two groups:group A,40 cases of double primary cancer with lung cancer as the first primary cancer,group B,106 cases of double primary cancer with lung cancer as the second primary cancer.The clinical and pathological data of the two groups were collected.Overall survival(OS)was analyzed by Kaplan-Meier method from the date of diagnosis to the date of death or follow-up of the second primary cancer.The differences between the two groups were compared by Log-rank test.Results:1.There were significant differences in gender(p<0.001),smoking history(p<0.001),drinking history(p=0.008),interval time between two kinds of tumors(p=0.009),size of lung tumors(p=0.039)and distant metastasis(p=0.046)between A and B groups;2.The independent factors influencing the prognosis of group A were lung tumor size(p=0.014),lymph node metastasis(p=0.006),distant metastasis(p=0.004).interval between two cancers(p=0.009),and radical resection of double cancers(p=0.024);3.The independent factors influencing the prognosis of group B were lymph node metastasis(p=0.007),distant metastasis(p=0.018),and treatment of primary cancer(p=0.013);4.The survival time of group A was 17.5 months,and that of group B was 18.6 months.There was no significant difference in the total survival time between the two groups(p=0.306).Conclusions:1.In group A,male patients,smokers and alcoholic drinkers were predominant.The larger the lung tumors,the more lymph node metastases,distant metastases,the shorter the interval between the two tumors and the less radical resection of the two tumors was performed,the worse the prognosis and the shorter the survival time of the patients.2.In group B,women,non-smokers and non-alcoholic drinkers were predominant.The more lymph node metastasis,distant metastasis,radiotherapy or chemotherapy individually of first primary cancer,the worse the prognosis and the shorter the survival time.3.There was no significant difference in survival time between groups A and B.The prognosis of patients with double primary lung cancer was not related to the sequence of lung cancer onset.