Clinical Observation Of Ma Ting Shuchuan Decoction On Asthma-chronic Obstructive Pulmonary Disease Overlap Syndrome

Objective: Observe the clinical efficacy and safety of Ma Ting Shu Chuan Tang on asthma-chronic obstructive pulmonary disease overlap syndrome(ACOS).Methods: Using randomized,parallel,and controlled clinical trial methods,60 patients with traditional Chinese medicine diagnosed with asthma syndrome and wind-phlegm obstruction syndrome and Western medicine with asthma-chronic obstructive pulmonary disease overlap syndrome(ACOS)were observed.The patients were randomly divided into two groups,A and B,group A was the basic treatment + Kechuanting mixture control group,group B was the basic treatment + Maqin Shuchuan decoction treatment group,the treatment course was 15 days,using the signs of symptoms and signs The score table,CAT score table and related physical and chemical examinations(including changes in lung function indexes,blood routine,immunological markers),etc.were used to evaluate the treatment effect.SPSS25.0 statistical software was used for data analysis to compare the clinical efficacy of the two groups;observation Adverse reactions and safety indicators(liver and kidney function,hematuria routine,electrocardiogram)during the medication process were used to evaluate the safety of Ma Ting Shu Chuan Tang.Results:The total effective rate of the control group was 83.33%;the total effective rate of the treatment group was 96.55%.The comprehensive therapeutic effect of the two groups was statistically significant(P<0.05).Comparison before and after treatment: CAT score,total syndrome,cough,expectoration,phlegm stickiness,fullness of breathing,chest fullness,phlegm in the throat,itchy nasopharynx,ears,nasal congestion,sneezing,runny nose,respiratory rate The scores were significantly decreased(P<0.05).In the control group,there was no significant improvement exceptfor nasal congestion,sneezing,runny nose,and pulse rate scores(P<0.05);the treatment group had FEV1,FEV1/FVC,SPO2,Ig A after treatment,Ig G,complement C3,and EOS% all improved significantly(P<0.05).The control group showed no significant improvement except for Ig A,Ig G,and EOS%,and the rest also improved(P<0.05).Comparison between groups: The CAT score results of the treatment group after treatment,the score of fullness of dyspnea on the 7th and 15 th days,and the improvement of the total syndrome,cough,and sputum scores on the 15 th day were better than the control group(P<0.05).After treatment,the improvement of FEV1,FEV1/FVC,SPO2,Ig A and Ig G in the treatment group was better than that in the control group(P<0.05).There was basically no adverse reaction during the application of Ma Ting Shu Chuan Tang,and the safety indicators were consistent or improved compared with the previous ones.Conclusion: Ma Ting Shu Chuan Tang is effective in improving symptoms and signs of ACOS(a syndrome of asthma and phlegm blocking lung syndrome),especially in improving the main symptoms;Ma Ting Shu Chuan Tang can improve lung function and immune function to a certain extent,Blood oxygen saturation and percentage of blood eosinophils,and better than Kechuanting Mixture;Ma Ting Shu Chuan Tang has high safety in clinical application.