The Influence Of Abnormal Thyroid Function On The Prognosis Of Patients With Acute Myocardial Infarction

[Objective]The aim of the present study is to evaluate the predictive role of thyroid hormones in the prognosis of patients with acute myocardial infarction(AMI).[Methods]Participants diagnosed with AMI from China PEACE prospective AMI study of 53 hospitals across 21 provinces in China were screened and followed up for 12 months.According to thyroid function profiles,the patients were divided into three groups,ie,euthyroid group,hypothyroidism group and hyperthyroidism group.The composite cardiovascular endpoint includes all-cause death,myocardial infarction,revascularization and heart failure.The risk of complex cardiovascular adverse events was compared among the three groups.[Result]A total of 2569 patients were included in this study,of which 594(23.1%)of the patients reached a composite cardiovascular endpoint.There were 433(21.3%)composite cardiovascular events in euthyroid group,133(30.9%)in hypothyroidism group and 28(27.5%)in hyperthyroidism group.After adjusting traditional risk factors,the risk of composite cardiovascular events in the hypothyroidism group was significantly higher than that of euthyroid group(HR=1.337,95%Cl:1.097-1.630,P=0.004),and the risk of composite cardiovascular events in hyperthyroidism group was not significantly increased(HR=1.361,95CI:0.927-1.998,P=0.116).Hypothyroidism was also significantly associated with the revascularization(HR=1.648,95%CI:1.047-2.595,P=0.031)and heart failure(HR=1.382,95%CI:1.066-1.792,P=0.014).[Conclusion]Hypothyroidism is a strong predictor of cardiovascular events in patients with AMI and might be directly...