Clinical Observation Of Guipi Decoction Combined With Compound Cistanche Yizhi Capsule In The Treatment Of Insomnia And Amnesia With Deficiency Of Both Heart And Spleen

ObjectivesIn this study,we observe the improvement of the symptoms of heart and spleen deficiency type insomnia patients who aslo have amnesia by taking orally Guipi Decoction and Compound desert cistanche intelligence-improving capsule.We want to know whether there is a positive effect on the treatment of insomnia,whether it can improve the efficacy,shorten the treatment time,and improve the quality of life of patients by inquiring the relationship between insomnia and amnesia,evaluating the prevention and improvement of daytime functional symptoms on the basis of treating insomnia.To provide evidence-based basis for further promotion of this application,provide new ideas and new methods for clinical treatment of insomnia.MethodsWe used a randomized controlled study to select 60 cases of heart and spleen deficiency type insomnia and amnesia patients in Beijing University of Traditional Chinese Medicine Dongzhimen Hospital encephalopathic outpatient department,and signed informed consents.They were randomly divided into 30 cases treatment group and 30 cases control group.The patients of treatment group took orally Guipi Decoction and Compound desert cistanche intelligence-improving capsule.The patients of control group only took orally Guipi Decoction.The total course of treatment was 28 days.After the treatment,we observed the changes of AIS score,TCM syndrome score and MMSE score to evaluate clinical efficacy.ResultsThe baseline data:In the end,60 cases of heart and spleen deficiency type insomnia and amnesia patients were enrolled in this study,30 cases treatment group and 30 cases control group.The treatment group included 10 males and 20 females with an average age of 48.03 years old and a course of 25.97 months.The control group included 14 males and 16 females with an average age of 45.1 years old and a course of 22.24 months.The basic data of gender,age,work nature,course of disease,combined disease,heart rate,blood pressure,SAS score,SDS score,depression severity index,AIS score,TCM syndrome score,MMSE score,etc.were statistically analyzed.There was no statistically significant difference(P>0.05),which was comparable.The AIS score:After treatment,the AIS indicator points and total scores in the treatment group and the control group were lower than before treatment,and the difference was statistically significant(P<0.05).We compare the AIS scores between treatment and control groups after treatment,the treatment group was better than the control group by improving the AIS total score,total sleep quality,and daytime physical function(including physical strength or spirit,such as memory,cognition and attention)(P<0.05).The TCM syndrome score:After treatment,the indicator scores and total scores of TCM syndromes in the treatment group and the control group were lower than those before treatment,and the difference was statistically significant(P<0.05).The treatment group was superior to the control group in improving TCM syndromes such as insomnia,eating less,and amnesia(P<0.05).MMSE score:After treatment,the MMSE scores of the treatment group and the control group before and after treatment were lower than the previous ones,and the difference was statistically significant(P<0.05).The treatment group was superior to the control group in improving recall ability and MMSE total score,and the difference was statistically significant(P<0.05).The clinical efficacy of insomnia:The treatment group and the control group each had 30 patients in each group.The treatment group was cured in 4 cases,markedly effective in 14 cases,effective in 12 cases,ineffective in 0 cases,and the total effective rate in the treatment group was 100%.The control group was cured in 1 case,markedly effective in 10 cases,effective in 13 cases,and ineffective in 6 cases.The total effective rate of the control group was 80%.The clinical efficacy of insomnia in the two groups was tested,P<0.05,the difference was statistically significant.The clinical effect of insomnia in the treatment group was better than that in the control group.The TCM syndrome efficacy of insomnia:After treatment,the treatment group was cured in 0 cases,markedly effective in 15 cases,effective in 14 cases,and ineffective in 1 case.The total effective rate of the treatment group was 96.67%.The control group was cured in 0 cases,markedly effective in 10 cases,effective in 14 cases,ineffective in 6 cases,and the total effective rate in the control group was 80%.The efficacy of TCM syndromes in the two groups was tested,the difference was not statistically significant(P>0.05).ConclusionsOral Guipi Decoction and Compound desert cistanche intelligence-improving capsule group and Oral Guipi Decoction group can effectively reduce AIS score,TCM syndrome score and MMSE score,it indicates that the treatment group and the control group have obvious clinical effects on the treatment of heart and spleen deficiency type insomnia and amnesia.In terms of AIS score,the treatment group can improve the quality of sleep more effectively,improve the body function during the day,and reduce the total score of AIS.The treatment of insomnia was more effective than the control group.In terms of TCM syndromes,the treatment group was superior to the control group in improving insomnia,eating less,and amnesia in TCM syndromes.In terms of MMSE score,the treatment group was superior to the control group in terms of improving recall ability and MMSE total score.In general,oral Oral Guipi Decoction and Compound desert cistanche intelligence-improving capsule has good clinical efficacy and is worthy of further promotion and application.