A Multi-center Cluster Randomized Controlled Trial Study On The Prevention Of Seasonal Influenza In Beijing With Pihuijiedu Decoction

Objective1.To explore the pathogen types,clinical features and TCM syndrome patterns of seasonal influenza in Beijing from 2018 to 2019.2.To prove that Pihui Jiedu Prescription is effective in preventing seasonal influenza.MethodThis study used a large sample,multicenter,cluster randomized controlled trial.During the winter and spring period from November 1,2018 to February 28,2019,from Guang'anmen Hospital of China Academy of Chinese Medical Sciences,Beijing YouAn hospital,Capital Medical University,the Southern District of Guang'anmen Hospital of China Academy of Chinese Medical Sciences,Beijing Fengtai Hospital of Integrated Traditional and Western Medicine,and Huguosi Chinese Medicine Hospital affiliated to Beijing University of Chinese Medicine Outpatient and emergency to collect influenza-confirmed and influenza-like cases that meet the criteria.To explore the main pathogen types,clinical features and distribution patterns of TCM syndromes of seasonal influenza.And through each influenza confirmed and influenza-like case,incorporate its close contacts to form a group of units.All units were randomly divided into experimental group and control group.The experimental group was given Pihui Jiedu Prescription,one dose per day,taken twice in the morning and evening,and followed up after 15days;The control group will give health education,issue health education cards,and do a good job of "flushing masks,window ventilation" and other influenza prevention measures.To compare the incidence of influenza-like cases and the rate of influenza-confirmed between the two groups,and to observe the effect of Pihui Jiedu Prescription on preventing seasonal influenza.Results1.A total of 277 cases of influenza diagnosis and influenza-like cases were included.(1)Virus type detection:108 cases of influenza A virus,accounting for 38.99%;3cases of influenza B virus,accounting for 1.08%;166 cases of negative,accounting for 59.93%;(2)Frequency of symptoms(>100 times):243 times(87.73%)of fever and aversion to cold,182 times(65.70%)of pharyngeal discomfort,173 times(62.45%)of cough,167 times of fatigue(60.29%),133 cases of body pain(48.01%),123 cases of cough(44.40%),and 107 cases of headache(38.63%);(3)TCM syndrome type distribution:197 cases of cold around the fire syndrome,accounting for 71.1%,46 cases of wind-cold syndrome,accounting for 16.6%,15 cases of wind-heat syndrome,accounting for 5.4%,9 cases of heat and toxicity invading pulmonary syndrome,accounting for 3.2%,8 cases of wind-wet syndrome,Accounting for 2.9%,2 cases of wind-dryness syndrome,Accounting for0.7%.2.A total of 650 close contacts of influenza were included,of which 335 were in the group of Pihui Jiedu Prescription,accounting for 51.5%,and 315 were in the health education group,accounting for 48.5%.(1)Influenza-like case statistics:25 cases of influenza-like cases occurred in the Pihui Jiedu Prescription tea group,accounting for 3.8%,310 cases of influenza-like cases,accounting for 47.7%;In the health education group,95 cases of influenza-like cases occurred,accounting for 14.6%,and there were no cases of influenza-like cases of 220,accounting for 33.8%.There was a statistically significant difference between the two groups(P<0.05);(2)Statistics of confirmed cases of influenza:20 cases of influenza confirmed in the Pihui Jiedu Prescription tea group,accounting for 3.1%,and 315 cases of undiagnosed influenza,accounting for 48.5%;The health education group confirmed 62 cases of influenza,accounting for 9.5%,and 253 cases of undiagnosed influenza,accounting for 39.8%.There was a statistically significant difference between the two groups(P<0.05);(3)Statistics on the number of people who went to outpatient clinics or emergency clinics due to influenza,There were 21 cases in the outpatient or emergency department of the Pihui Jiedu Prescription tea group,accounting for 3.2%,and 314 cases,accounting for 10.3%,who did not;There were 67 cases of health education going to outpatient or emergency clinics,accounting for 10.3%;and 248,accounting for 38.2%,who did not.After chi-square test,the difference between the two groups was statistically significant(P<0.05).Conclusion1.Seasonal influenza in Beijing is mainly caused by influenza A in 2018-2019.Symptoms are mainly characterized by fever,aversion to cold,pharyngeal discomfort,headache,body pain,cough,sputum,and fatigue.TCM syndromes are mainly cold around the fire syndrome.2.Pihui Jiedu Prescription has a definite curative effect in preventing seasonal influenza.