Theory And Clinical Research On Seasonal Distribution Of TCM Syndromes Of Depression

Objective:To study and discuss the relationship between the distribution of TCM syndromes and seasons of depression through ancient medical records and clinical investigation.Methods:1.Theory research of ancient medical records;2.Clinical epidemiological investigation.Result:Theoretical discussion:The ancients paid attention to the influence of season on emotional diseases.1.Individual factors and seasonal factors are important factors for the occurrence of emotional disorders.Individual factors are mainly age and constitution;seasonal factors include:lack of yang-qi in winter,disorder of qi in spring;qi stagnation and fire of liver,rising of liver-yang in spring,inflammation of liver-fire;liver failure and catharsis,liver-qi multiplying spleen in spring,spleen deficiency and dampness.2.The treatment of emotional disorders mainly includes drug treatment,emotional therapy and prevention of emotional disorders.The main principles of drug therapy are nourishing yin and clearing heat,nourishing mind and calming mind,dispelling Qi and depression,resolving phlegm and resuscitating orifices.In the aspect of prevention,the ancients paid attention to the early prevention of patients with emotional disorders before changing seasons.Clinical study:A total of 107 patients with depression were collected,with an average age of 30.1 years and an average course of 15.1 months.Female patients were more than male patients,accounting for 68.2%of the total number.The incidence season is high in spring,followed by winter,autumn again,and summer at least,as follows.1.Seasons and Syndromes:(1)Liver depression and spleen deficiency are the most common syndromes of depression in the whole year and every season.The number of TCM syndromes of depression patients in the whole year is in the order of liver depression and spleen deficiency,heart-liver-fire prosperity,phlegm turbidity,liver-kidney Yin deficiency,heart-spleen deficiency,qi stagnation and blood stasis(P<0.01).(2)The distribution of syndrome types in spring from high to low is:liver depression and spleen deficiency syndrome,liver and kidney yin deficiency syndrome,phlegm turbidity syndrome and heart-liver-fire prosperity syndrome,heart-spleen deficiency syndrome,qi stagnation and blood stasis syndrome(P<0.01).The distribution of summer syndrome types from high to low is:liver depression and spleen deficiency syndrome,heart-liver fire prosperity syndrome,phlegm turbidity intrinsic syndrome,liver-kidney Yin deficiency syndrome,heart-spleen deficiency syndrome,qi stagnation and blood stasis syndrome(P<0.01).The distribution of autumn syndrome types from high to low is:liver depression and spleen deficiency,heart-liver-fire prosperity,liver-kidney Yin deficiency,phlegm turbidity,heart-spleen deficiency,qi stagnation and blood stasis(P<0.01).Distribution of winter syndrome types from high to low is:liver depression and spleen deficiency syndrome,heart and liver fire prosperity syndrome,phlegm turbidity syndrome,liver and kidney yin deficiency syndrome,heart and spleen deficiency syndrome,qi stagnation and blood stasis syndrome(P<0.01).(3)Heart-liver-fire vigorous syndrome in summer and autumn was significantly more than that in winter and spring(P= 0.047<0.05).(4)The evidence of phlegm turbidity in spring is significantly more than that in autumn.(P=0.017<0.05)(5)The deficiency of liver and kidney Yin Syndrome in spring was significantly more than that in winter and summer(P=0.044 and 0.044,respectively,were less than 0.05).2.Individual factors and syndrome types:(1)Age:45-65-year-old depressive middle-aged and elderly patients are more likely to suffer from Phlegm-turbidity syndrome(P=0.028<0.05);(2)gender:there is no significant difference in the distribution of depression syndrome types between different genders.(3)In the course of disease,the syndrome of heart-liver-fire exuberance and qi stagnation and blood stasis were more distributed in depression patients whose course was more than one year(P was 0.030 and 0.016,respectively,less than 0.05).3.The correlation between meteorological factors and syndrome types:(1)Quantitative distribution of liver depression and spleen deficiency syndrome in four seasons was negatively correlated with sunshine hours(P<0.01);(2)Four seasons distribution of qi stagnation and blood stasis syndrome was positively correlated with sunshine hours in four seasons(P<0.01);(3)Four seasons distribution of phlegm accumulation syndrome and heart-spleen deficiency syndrome was positively correlated with PM2.5 concentration(P<0.01);(4)Four seasons distribution of heart-liver fire prosperity syndrome was negatively correlated with PM2.5 concentration.The correlation was significant(P<0.01).Conclusion:1.The distribution of some syndromes of depression has seasonal rhythm.(1)Liver depression and spleen deficiency syndrome is less in spring and more in winter:affected by sunshine hours;(2)phlegm turbidity syndrome is more in spring:affected by PM2.5 concentration;(3)Heart-liver fire syndrome is more in summer and autumn:affected by PM2.5;(4)Liver-kidney Yin deficiency syndrome is higher in spring:affected by sunshine hours.2.The distribution of some types of depression did not show seasonal rhythm.(1)Qi stagnation and blood stasis syndrome:the course of disease has greater impact;(2)deficiency of both heart and spleen syndrome:affected by meteorological factors and individual factors,it has complexity.