Clinical Observation Of Jiajianxiebaisan In Treating Children's Cough Variant Asthma (syndrome Of Lung Heat And Yin Deficiency)

Objective:To observe the curative effect and the influence on fractional exhaled nitric oxide(Fe NO)of modified Xiebaisan in the treatment of variant asthma cough(CVA)(lung heat and yin deficiency syndrome)in children.Method:59 child patients with CVA were randomly and evenly divided into observation group and control group by random number table method.30 child patients in the observation group were treated with modified Xiebaisan for 2 weeks.29 child patients in the control group were treated with montelukast sodium chewable tablets for 2weeks.Observe the changes of cough scores,traditional chinese medicine(TCM)syndrome scores,curative effect,overall curative effect,and Fe NO scores before and after treatment in two groups of child patients.Results:1.Modified Xiebaisan could effectively improve the score of cough syndrome,and there was no statistical significant difference(P>0.05)compared with the control group.2.Modified Xiebaisan could effectively improve the TCM syndrome scores and there was statistical significant difference(P < 0.01)compared with the control group.3.The curative effect: The total effecttive rate of the observation group was 93.3%,the control group was 86.2%.The difference between two groups was no statistical significance(P>0.05),two groups gave the same effect.4.The overall curative effect: The total effecttive rate of the observation group was 90.0%,the control group was 69.0%.The difference between two groups was significant statistical significance(P<0.01),the observation group was better than control group.5.Fe NO in both groups decreased significantly after treatment.It was statistical significance(P<0.01)compared before and after treatment in the group.The difference of Fe NO compared before and after treatment between two groups was no statistical significance(P>0.05).6.Safety index of two groups before and after treatment had no obvious change,and no serious adverse events,Modified Xiebaisan had high safety.Conclusion: Modified Xiebaisan has a certain curative effect in the treatment of child patients with CVA(lung heat yin deficiency syndrome),and can reduce the cough scores,TCM syndrome scores and Fe NO.