| Objective Previous national survey suggested that dyslipidemia is an increasing epidemic in urban population in China.In this study,we retrospectively analyzed the trends of lipid profile in a large Chinese urban population in Nanjing from 2009 to 2015.Methods A total of 236,945 adults(age ?20 years old)who undertook a health check between 2009 and 2015 in our medical examination center were included in the analysis.Fasting total cholesterol,high-density lipoprotein(HDL)cholesterol,low-density lipoprotein(LDL)cholesterol and triglyceride(TG)were measured by standard methods.Mean values were presented for lipid profile and age-standardized levels of lipid profile were calculated in line with the population distribution in China in 2010.Trends of continuous variables with survey years were determined with linear regression.A two-sided P value less than 0.05 was considered statistically significant.All data analyses were performed using the SPSS version 18.0.Results An increasing secular trend was observed in LDL cholesterol levels from 2009 to 2015 in both males and females.The LDL cholesterol increased from 2.46 mmol/L(in 2009)to 2.56 mmol/L(in 2015)in males and 2.36 mmol/L(in 2009)to 2.48 mmol/L(in 2015)in females(P values for trends<0.01 for both).Further age-specific analysis showed that the increasing trends of LDL cholesterol largely existed in the age groups of 20-39 years and 40-59 years in males rather than in those older than 60 years.The prevalence of either abnormal fasting glucose or abnormal blood pressure was increased with the age groups among the people with dyslipidemia.In people over 70 years old with dyslipidemia,34.4% in males and 30.9% in females complicated with abnormal fasting glucose,62.9% in males and 68.5% in females complicated with abnormal blood pressure,respectively.Conclusion Dyslipidemia is an increasing epidemic in urban population in Nanjing,characterized by a rising trend of LDL cholesterol.The trends of lipid profile among different age groups suggested that more attention should be paid to the middle-age men for the management of dyslipidemia and primary prevention of cardiovascular disease.The prevalence of either abnormal fasting glucose or abnormal blood pressure was increased with ages among the people with dyslipidemia.Thus,it is essential to strengthen the routine screening and monitoring of blood glucose and blood pressure for the elderly.Objective To investigate the clinical profile characteristics and the status of related complications in the patients with early onset type 2 diabetes mellitus(EOD).Methods A total of 1512 patients with type 2 diabetes mellitus who hospitalized in Nanjing Drum Tower Hospital were included in the analysis.Patients were divided into two groups according to the age of diagnosis: 372 cases of early-onset diabetes group(diagnostic age?40 years),1140 cases of late-onset diabetes group(diagnosis age> 40 years).All patient records were collected and the characteristics of clinical profile and the status of associated complications were compared between the two groups.Results Compared to LOD group,diastolic blood pressure(DBP),body mass index(BMI),proportion of family history of diabetes,proportion of family history of maternal diabetes,fasting blood glucose,Hb A1 c,alanine aminotransferase(ALT),aspartate aminotransferase(AST),uric acid(UA),triglyceride(TG),total cholesterol(TC)in patients of EOD group were higher(P < 0.05).Age,diagnosis age,systolic blood pressure(SBP),postprandial insulin,postprandial C-peptide,and HOMA-? in patients of EOD group were lower(P<0.05).There was no significant difference in the course of disease,postprandial blood glucose,fasting insulin,fasting C-peptide,HOMA-IR and proportion of combined hypertension,non-alcoholic fatty liver,smoking history and drinking history between the two groups(P>0.05).Conclusion Patients with early onset type 2 diabetes mellitus have significant disorders of blood glucose and lipid profile.They more easily complicate diabetic retinopathy and diabetic nephropathy. |
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