Family And Clinical Analysis Of HLA Fully Compatible Hematopoietic Stem Cell Transplantation Between Parent And Child

Objective:To analyze the characteristics and prognosis of parent-child HLA-matched hematopoietic stem cell transplantation.Methods:A total of 97 patients with hematopoietic stem cell transplantation were enrolled in this study,which consist of 14 patients with parent-child full HLA-match.To analyze the characteristics of their HLA loci,Explore the prognosis between different donors(parent-child-matched-HSCT,UD-HSCT,Sib-HSCT,parent-child-Hi-HSCT).Results:All the HLA loci of 14 patients with parent-child HLA-matched were common alleles.There were 10 patients have haplotype A * 02-B * 46,A * 30-B * 13.Of 97 subjects(66 males and 31 females),the median age was 24(7~63)years(P = 0.009).The median duration of all patients from diagnosis to transplantation was 4(1~36)months(P = 0.022).Pretreatment regimen mainly on Modified BU / CY scheme.All the patients were treated with ATG to prevent GVHD,in addition to 24 Sib-HSCT patients and 1 UD –HSCT patient.Patients receiving parent-child HSCT had advanced recovery of platelet,when compared with those in UD-HSCT and Hi-HSCT group(P = 0.045,P = 0.035).The incidence of a GVHD between the four groups was 42.9%,37.5%,56.3%,59.3%(P=0.362)and c GVHD was 35.71%?45.8%?34.4%?37.0%(p=0.839).There was no significant difference in the III~IV degree of a GVHD and extensive c GVHD(P=0.695?P=0.516).At the end of the follow-up,6 patients relapsed and 22 patients died(2 cases of parent-child group,6 cases of UD-HSCT,8 cases of Sib-HSCT,6 cases of HiHSCT),The 3 years' progression-free survival(PFS)and overall survival(OS)in four groups have no significance(P=0.946?P=0.866).Conclusion:In contrast to the patients with Sib-HSCT,the modified BU/CY conditioning regimen with ATG is more successful in parent-child-matched-HSCT.