Synthesis, Separation And Alkoxylation Of Semi-methyl Citrulline

Cucurbit[n]urils has a hydrophobic cavity,two ports that distribute negatively charged carbonyl groups,and a positively charged outer wall.These characteristics make the Q[n]s as the host molecule in the Q[n]-based host-guest chemistry,coordination chemistry,and fusion of the host-guest coordination chemistry.There are broad prospects for development.Based on the previous work research of the predecessors,this paper mainly explores the following aspects:（1）Because the presence of different metal ions and anions can affect the interaction between the host and guest molecules of the Q[n]s,if this effect may synergistically promote the interaction between the host and guest molecules,it may also compete to weaken the interaction between the host and guest molecules.This changes the original mode and nature of the main body and guest molecules of the Q[n]s.In this section,the hemimethyl-substituted cucurbit[6,7]urils SHMeQ[6]and SHMeQ[7]synthesized and separated in our laboratory were used to prepare a fluorescent probe with a styrene dye compound t-DSMI,which further were used to detecte various anions.The interaction between t-DSMI and SHMeQ[6]in aqueous solutionwithpH=6wasstudiedbyNMRspectroscopy,fluorescence spectrophotometry,and UV-vis absorption spectrometry.The results showed that SHMeQ[6]can include t-DSMI guest and form the t-DSMI@SHMeQ[6]host-guest inclusioncomplexatroomtemperature.Moreover,theresponseof t-DSMI@SHMeQ[6]host-guest inclusion complex to anions was further investigated.The experimental results revealed that the t-DSMI@SHMeQ[6]host-guest inclusion complex can selectively recognize H₂PO₄^-,BF₄^?and HSO₄^?,and within a certain concentration range,there are linear relationship with the change of absorption value via the concentration of H₂PO₄^-,BF₄^?and HSO₄^?anions and the detection limits were2.07×10^-66 mol·L^-1,1.67×10^-66 mol·L^-11 and 1.93×10^-66 mol·L^-1,respectively.（2）Based on the fact that coordination between Q[n]s and metal ions can form porous supramolecular coordination polymers,the porous layered coordination polymers was prepared through the interaction of K⁺ion and SPMeQ[5]in the presence of hydroquinone as a structure directing agent in this paper.The experiments revealed that this SPMeQ[5]-based porous layered supramolecular coordination polymer had adsorption characteristics for different compounds（such as dyes and polycyclic compounds）,especially after absorption of 2-[4-（dimethylamino）styrene]-1-methypyridinium iodide（G1）,proflavin（G2）,neutral red（G3）,acridine orange（G4）,forming solid fluorescent probes or sensors that is enhanced by fluorescence or changes in color.Further experiments showed that these fluorescent materials had good selectivity response to methanol,ethanol and formaldehyde.（3）In this paper,based on the previour researches,SHMeQ[6]was selected as the crosslinking agent,acrylamide as the monomer,ammonium persulfate as the oxidant and the initiator to synthesize the SHMeQ[6]-bridged acrylamide polymer,The polymer can form vesicles in aqueous medium and can be used in drug delivery research.