Asymmetric Study Of Lewis Acid-catalyzed Nitrate Esterification Of ?-ketoesters

The chiral compounds are not only widely found in various kinds of drugs and natural products,but also have been applied in many fields such as chemistry,medicine,biology and so on.Since last century,asymmetric metal catalysis,compared with other kind of asymmetric catalytic methods,is a more simpler and economical way to construct optical organic compounds.But this approach has not been used in the asymmetric nitratationThe main contents of this paper are:Organic nitrate compounds,which widely exist in drugs or natural products,are a kind of valuable organic compounds.The functional group plays a decisive role for some certain properties.Thus,it is important to develop some new kinds methodologies for the synthesis of organic nitrate compounds.In this thesis,we investigated a method of asymmetric nitratation catalyzed by inexpensive zinc salt.The asymmetric zinc catalyzed nitric acid esterification of ?-ketoesters/?-ketoamides can be realized for the first time by this method.Because ligand or metal what has been used in this reaction can be purchased from market.And the reaction conditions,with an excellent yield and enantioselectivities of products,are mild.