The Preparation Of FePt@MoS₂ Nanomaterials And Its Anti-tumor Research

The goal of cancer treatment is to cure primary tumors and prevent the recurrence of metastatic tumors.However,because of the molecuLar complexity and drug resistance of tumors,monotherapies are still not the best treatment.Therefore,the purpose of this study is to develop a muLtifunctional therapeutic nano-platform for effective cancer treatment.Simply,immunotherapy is the use of the body's natural defenses to fight disease,especially uncontrolled cancer.It is achieved by restoring or attempting to restore the immune system to its previous non-morbid.In recent years,with the deepening of the research on tumor immunotherapy,researchers have adopted a variety of methods to reactivate the immune system suppressed by tumor cells,so as to achieve the goal of tumor immunotherapy.Photothermal therapy is a new non-invasive tumor treatment method developed in recent years,which uses the nano-particles enriched at the tumor site as photosensitizer to convert light energy into heat energy and kill tumor cells by thermal ablation.In view of the limitations of a single therapy to treat tumors,more and more researchers are studying a variety of synergistic methods to treat tumors together.Synergistic therapy,as a particuLarly meaningfuL treatment method,has the advantages of self-evident,good targeting,small side effects and high therapeutic efficiency.In this paper,FePt@MoS₂ Nanoparticles with pH and NIR responses were prepared for magnetic resonance imaging and electronic computed tomography imaging.A simple hot-melt method is used to synthesize FePt Nanoparticles with a particle size of 4⁵nm in one step.The layer MoS₂ was obtained by lithium intercalation method,and then FePt@MoS₂ Nanoparticles was obtained by reaction,finally through the modification of target group HS-PEG-FA,it was successfuLly targeted to the cancer cells of folic acid receptor.FePt@MoS₂ Nanoparticles releases Fe²⁺in tumor cells with low pH,catalyzing H₂O₂ decomposition into cells to produce a large amount of reactive oxygen species?ROS?.FePt and MoS₂,which have strong near-infrared photothermal conversion ability,can promote the release of reactive oxygen species in acidic tumor environment under the 808 nm laser irradiation,and increase the temperature of tumor site rapidly in a short period of time,thus inducing apoptosis of cancer cells.Combined with immune adjuvant CpG ODN and Immune blocker Anti-CTLA4,the elimination of metastatic tumors by immunotherapy was studied.In addition,Iron?Fe?-based and platinum?Pt?-based nanoparticles have been extensively studied as candidates for MRI T2 or CT contrast agents due to their effective contrast enhancement effects in the body.Both in vivo and in vitro experiments have proved that FePt@MoS₂ Nanoparticles is a kind of anti-tumor nanomaterials with good biocompatibility and non-toxic.