Study On The Assembly, Structure And Properties Of Aromatic Carboxylic Acid-nitrogen Heterocyclic Eutectic Compound

In this thesis,three drug molecules,Fenbufen,Naproxen and Oxaprozin,were selected to react with a series of N-heterocycles to generate eight new pharmaceutical co-crystals by different methods.These co-crystals were structurally determined and characterized by element analysis,IR,PL,DSC,powder and single crystal X-ray diffraction.And the different experimental strategies of these co-crystals were also performed.Meanwhile,six different dosage forms based on compounds 5 and 6 have been prepared,which was then tested through monitoring the pharmaceutical indexes.Structure analyses shows that different drug molecules and co-crystal formers have a profound impact on the structures and properties of target co-crystals.The Fenbufen molecules in compounds 1-4 display diverse conformations.Compounds 5 and 6present helical structures while compounds 7 and 8 exhibits interesting host-guest and1 D tape structures.The pharmaceutical indexes of the six different dosage forms meet the requirement of Pharmacopoeia of People’s Republic of China.