Study On The KIF18A Promotes Proliferation,Invasion And Metastasis Of Head And Neck Squamous Cell Carcinoma

Objective: To investigate the expression of KIF18 A in HNSCC and its infulence on proliferation,invasion and metastasis of head and neck squamous cell carcinoma(HNSCC)cells.Methods: Expression level of KIF18 A m RNA in tissues and cells of HNSCC was detected by q RT-PCR,and expression level of KIF18 A protein in HNSCC was detected by Western Blot.The expression of KIF18 A was up-regulated and down-regulated in Tu686 and 6-10 b cells,and the proliferation,invasion and metastasis of the cells were detected by CCK8 assay,plate cloning assay,scratch assay and Transwell assay.Results: Our current study demonstrated that KIF18 A was highly expressed in HNSCC tumor tissues and cell lines.After upregulation of KIF18 A in Tu686 and 6-10 b cells,cell proliferation,invasion and metastasis were significantly enhanced.After down-regulation of KIF18 A expression in Tu686 and6-10 b cells,cell proliferation,invasion and metastasis were significantly reduced.Conclusions: KIF18 A is relatively highly expressed in HNSCC and promotes tumor proliferation,invasion and metastasis.It plays an important role in HNSCC and targeting KIF18 A may be a potential therapeutic strategy for the HNSCC.