Correlation Between Serum 25-hydroxyvitamin D Level And Chronic Cerebral Hypoperfusion And Distribution Of TCM Syndromes

Objective:This article aims to analyze the TCM syndromes,gender,age,25-hydroxyvitamin D and other biochemical indexes in patients with chronic cerebral hypoperfusion by measuring serum 25-hydroxyvitamin D levels and their distribution characteristics of TCM syndromes inchronic cerebral hypoperfusion,and to explore the relationship between 25-hydroxyvitamin D and chronic cerebral hypoperfusion,and explore whether vitamin D can improve the mechanism of chronic cerebral hypoperfusion,with a view to providing diagnosis and treatment of chronic cerebral hypoperfusion More clinical ideas.Methods:The subjects were from the outpatient department of geriatric department of the First Affiliated Hospital of Tianjin University of traditional Chinese medicine from March 2019 to March 2020.The patients diagnosed aschronic cerebral hypoperfusion by carotid color Doppler examination combined with transcranial color Doppler and the patients without chronic cerebral hypoperfusion at the same time were voluntary participants and signed the informed consent.Collect patients' related laboratory and examination data such as 25-hydroxyvitamin D,the database was established and spss22.0 software was used for correlation analysis.Result:1.Basic information: Among the 232 patients included,123 patients were divided intochronic cerebral hypoperfusion group and 109 patients without chronic cerebral hypoperfusion group(control group)according to transcranial color Doppler and carotid color Doppler results.There was no significant difference in gender,age,chronic diseases(hypertension,diabetes,coronary heart disease)between the two groups(P>0.05),the general data of the two groups are relatively balanced and comparable.2.Comparison of 25-hydroxyvitamin D levels and related laboratory indicators between the two groups: the experimental group vitamin D(10.30,15.20);the control group vitamin D(15.10,23.30),the difference was statistically significant.Through correlation comparison,25-hydroxyvitamin D levels were positively correlated with HDL-C and Ca,and there was statistically difference;negatively correlated with IPTH levels,there was statistically difference;it was positively correlated with gender,TC,LDL-C,and negatively correlated with P level,but there was no statistical difference.3.Correlation between 25-hydroxyvitamin D level and chronic cerebral hypoperfusion: Through correlation analysis,we found that 25-hydroxyvitamin D was negatively correlated with IMT(P<0.05),which was statistically significant;blood velocity of bilateral vertebral artery and left internal carotid artery,which was statistically significant.25-(OH)D,TC and Ca are protective factors of abnormal blood flow velocity of TCD.4.Distribution characteristics of TCM syndromes inchronic cerebral hypoperfusion and its correlation with 25-hydroxyvitamin D levels: TCM syndrome and 25-hydroxyvitamin D have correlation,with statistical significance(P<0.05).Among the included population,the level of vitamin D in Qi deficiency and blood stasis type was the lowest,followed by Qi stagnation and blood stasis type,and the phlegm and blood stasis type were the highest.Among patients with CCH,the level of vitamin D in Qi stagnation and blood stasis type was the lowest,followed by Qi deficiency and blood stasis type,and the phlegm obstruction and blood stasis type were the highest,all lower than normal levels;in the control group,25-(OH)D levels were distributed,with phlegm blocking blood stasis type highest,qi stagnation blood stasis type second,and qi deficiency blood stasis type second.There are differences in blood flow velocity of 25-hydroxyvitamin D,Ca,TG,LDL-C and RICA in different TCM syndrome groups of CCH patients.The levels of 25-hydroxyvitamin D in Qi deficiency and blood stasis type and phlegm blocking blood stasis type are higher than Qi stagnation and blood stasis type,and phlegm blocking blood stasis type are higher than in Qi stagnation blood stasis type;blood stasis type TG level is higher than Qi stagnation blood stasis type;Qi stagnation blood stasis type RICA blood flow speed is faster than Qi deficiency blood stasis type;all have statistical significance.Conclusion:1.Vitamin D deficiency or deficiency is widespread in Tianjin and surrounding areas;2.The lower the 25-hydroxyvitamin D level,the higher of the IPTH,the lower the Ca and HDL-C levels;3.The level of 25-hydroxyvitamin D is correlated with chronic cerebral hypoperfusion.The lower the level of 25-hydroxyvitamin D,the thicker of the IMT thickness,and the slower the blood flow velocity of the bilateral vertebral artery and the left internal carotid artery.25-(OH)D is a protective factor for abnormal blood flow velocity of TCD.It is speculated that 25-(OH)D level is correlated with CCH.But the causal relationship between 25-hydroxyvitamin D level and chronic cerebral hypoperfusion remains to be confirmed by further studies.4.The level of 25-(OH)D is related to the distribution characteristics of CCH TCM syndromes.The blood flows velocity of 25-(OH)D,Ca,TG and RICA is different between CCH patients with different TCM syndromes.The overall distribution of 25-(OH)D level in the population is phlegm and blood stasis type> Qi stagnation and blood stasis type> Qi deficiency and blood stasis type;the distribution characteristics of CCH TCM syndromes are qi deficiency and blood stasis type> phlegm and blood stasis type> Qi stasis and blood stasis type,25-(OH)D level distribution is phlegm and blood stasis type> Qi deficiency and blood stasis type> Qi stagnation and blood stasis type,it is speculated that 25-(OH)D and CCH have mutual influence on the operation of Qi machine.