Study On Distribution And Related Factors Of TCM Syndromes Of Arrhythmia Complicated With OSAHS

Purpose To explore the distribution characteristics of TCM syndroms in patients with arrhythmia complicated with OSAHS.Analysis of TCM syndroms associated with gender,age,body mass index,OSAHS lesion degree,relevant objective indexes.At the same time,to explore the relationship between arrhythmia with OSAHS lesion degree and related factors.so as to provide syndrome differentiation basis for TCM treatment of arrhythmia complicated with OSAHS.Methods This study collected patients with arrhythmias who snored in the Department of Cardiology of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from March 2018 to January 2020.All the cases,met the inclusion criteria and exclusion criteria,tested by Polysomnography.According to the examination results,they were divided into arrhythmia with OSAHS group(n=116)and arrhythmia non-OSAHS group(n=30).The date of patients were statistically analyzed,including general conditions,previous medical history,biochemical indexes and cardiac color Doppler ultrasound.According to the Guidelines for Diagnosis and Treatment of Internal Diseases in Traditional Chinese Medicine(2008)and Internal Medicine of TCM,TCM syndrom differentiation was performed for patients with arrhythmia,and the patients were divided into seven groups:heart deficiency and timidity syndrome,heart-spleen deficiency syndrome,yin deficiency with effulgent fire syndrome,devitalization of heart yang syndrome,stasis of heart vessel syndrome syndrome,phlegm-fire disturbing heart syndrome and water-rheum intimidating the heart syndrome.The date collated were analyzed by SPSS25.0 statistical software.Results1.The age and hypertension prevalence rate of arrhythmia patients with OSAHS were higher than those of arrhythmia patients without OSAHS(P<0.05).2.Among arrhythmia patients with OSAHS,the AHI and BMI of young and middle-aged patients were significantly higher than those of elderly patients(P<0.05).The AHI of malepatients was higher than that of female patients(P<0.05).The AHI of obesity group was higher than that of overweight group(P<0.05).The AHI of patients with hyperlipidemia was higher than that of patients without hyperlipidemia(P<0.05),and the AHI of patients with type2 diabetes mellitus was higher than that of patients without type 2 diabetes mellitus(P<0.05).3.LAD,LVEDD and IVS of arrhythmia patients with OSAHS were higher than those of arrhythmia without OSAHS(P<0.05).In arrhythmia with OSAHS group,the level of TG in severe group was significantly higher than that in mild group(P<0.05),and the levels of HDL-C in moderate group and severe group were lower than those in mild group(P<0.05).4.The frequency distribution of TCM syndromes in patients with arrhythmia complicated with OSAHS is as follows: heart-spleen deficiency syndrome > phlegm-fire disturbing heart syndrome > heart deficiency and timidity syndrome > stasis of heart vessel syndrome > yin deficiency with effulgent fire syndrome > devitalization of heart yang syndrome >water-rheum intimidating the heart syndrome.5.The age of arrhythmia patients with OSAHS was in the order,heart-spleen deficiency syndrome > heart deficiency and timidity syndrome > stasis of heart vessel syndrome >phlegm-fire disturbing heart syndrome.Patients of heart-spleen deficiency syndrome,heart deficiency and timidity syndrome were older than patients of phlegm-fire disturbing heart syndrome(P<0.01).6.There were statistically significant differences in BMI among different TCM syndromes in patients with arrhythmia complicated with OSAHS.BMI in patients with phlegm-fire disturbing heart syndrome was higher than that in patients with heart-spleen deficiency syndrome(P<0.01).7.There were differences in the distribution of AHI and oxygen reduction index among different TCM syndromes of patients with arrhythmia complicated with OSAHS(P<0.05).AHI in patients with phlegm-fire disturbing heart syndrome was higher than that in patients with heart-spleen disturbing syndrome(P<0.01),and the oxygen reduction index in patients with phlegm-fire disturbing heart syndrome was higher than that in patients with heart-spleen deficiency syndrome and heart deficiency and timidity syndrome(P<0.05).8.There were statistically significant differences in the distribution of CHO among different TCM syndromes in patients with arrhythmia complicated with OSAHS.The level of CHO inpatients with phlegm-fire disturbing heart syndrome and stasis of heart vessel syndrome was higher than that in patients with heart-spleen deficiency syndrome(P<0.05).Conclusion1.The age,prevalence rate of hypertension,LAD,LVEDD and IVS of arrhythmia patients with OSAHS were higher than those of arrhythmia patients without OSAHS,suggesting that these factors related to the pathogenesis of arrhythmia complicated with OSAHS.2.Among the arrhythmia patients with OSAHS,the degree of sleep apnea was more severe in male,young and middle-aged,obese,complicated with type 2 diabetes and hyperlipidemia patients.3.Heart-spleen deficiency syndrome,phlegm-fire disturbing heart syndrome,heart deficiency and timidity syndrome,stasis of heart vessel syndrome are common TCM syndromes in patients with arrhythmia complicated with OSAHS.4.Age,BMI,AHI,oxygen reduction index and CHO have certain influence on the distribution of TCM syndrome types of arrhythmia complicated with OSAHS.The patients with heart-spleen deficiency syndrome were older,and the patients with phlegm-fire disturbing heart syndrome were younger,obese and the degree of OSAHS was more serious.