Preparation And Characterization Of Photo-inspired Nanocomposites And Evaluation Of Their Antibacterial Activity

Antibiotics play an important role in the treatment of infectious diseases for improved human healthcare.However,the growing threat of multidrug-resistant bacteria is shrinking the availability and effectiveness of antibiotics.Here,we introduce two types of nanocomposites for antibacterial applications that shows potential of overcoming multidrug resistance.The first,a biocompatible and biodegradable clay material was used as a matrix to simultaneously dope silver nanoparticles(AgNPs)and a photosentizer Chlorin e6(Ce6)for antibacterial applications.The fabricated clay-silver-Ce6 nanocomposites can effectively kill a wide range of bacteria,including Gram-positive bacteria(Staphylococcus aureus and methicillin-resistant Staphylococcus aureus)and Gram-negative bacteria(Escherichia coli and Pseudomonas aeruginosa).What's more photosensitizer Chlorin e6 doped silica was synthesized as a second nanocomposite.This hybrid structure exhibits enhanced photostability and high antibacterial effiffifficiency towards Staphylococcus aureus(S.aureus)and methicillin-resistant S.aureus(MRSA).Importantly,we demonstrate that two types of nanocomposites are highly effective for in vivo wound disinfection with minimal side-effects.Therefore,those nanocomposites could be potentially utilized in clinical phototherapy for treating various bacterial infections.