The Efficacy Evaluation Of Endoscopic Nasal Polyp Surgery With Middle Turbinate Preservation And Modification And The Expression And Significance Of Ki67 And VEGF In Vesicle Tissue

Objective:To explore the efficiency of endoscopic sinus surgery with middle turbinate preservation and modification for treating chronic rhinosinusitis with nasal polyps,and the expression and significance of Ki67 and VEGF in the vesicle tissue after surgery.Methods:Sixty two patients with chronic rhinosinusitis and nasal polyps were treated in department of otorhinolaryngology head and neck surgery in Pingxiang People's Hospital from January 2019 to October 2019 were retrospectively analyzed.These cases were randomly assigned into two groups.One group were treated with endoscopic sinus surgery of partial resection of middle turbinate,and the other group were treated with the endoscopic sinus surgery of preservation and modification of the middle turbinate.Lund-Kennedy endoscopic mucosal morphology score,visual analogue scale(VAS)score,the nasal sinusitis disease specific quality of life scale(SNOT-20)score and the efficiency of two surgery were analyzed.In addition,the expression and significance of Ki67 and VEGF in vesicle tissue were analyzed..Above all indexes was attributed to assess condition and control rate of diseases.Results:No difference in control rate between the two groups(P > 0.05),but there was difference in the complete control ratefour months after surgery(P < 0.05),No difference in efficiency between the two groups six months after surgery(P > 0.05).No difference in Lund-Kennedy score before surgery between the two groups(P >0.05),but the difference was significant 12 weeks after surgery(P < 0.05).VAS score before and 12 weeks after surgery showed no statistically difference(P > 0.05).SNOT – 20 score was found no statistical difference before operation between the two groups,however the difference was significant between before operation and 12 weeks after operation in two groups except for the item of sinus reflux(throat).In addition,the difference was significant 12 weeks after surgery in the item of sinusreflux(throat)(P < 0.05).No difference in the other items after surgery between the two groups(P> 0.05).Expression of Ki67 and VEGF in the vesicle tissue was decreased after operation,and there was difference between the two groups 12 weeks after operation(P < 0.05).Conclusion:Endoscopic sinus surgery with middle turbinate preservation and modification for the treatment of chronic rhinosinusitis with nasal polyps can recover the physiological function better,accelerate the process of epithelialization in the operation cavity and achieve better therapeutic effect.In addition,the expression of Ki67 and VEGF in the vesicle tissue is decreased after surgery.