Clinical Study On The Difference Of Brain Functional Network Between High Myopia And Low Myopia Based On Voxel Level Degree Centrality

Objective:The aim of present study was to investigate the difference of brain functional networks of brain activity in patients with high myopia and low myopia through the voxel-level degree centrality(DC)method of the resting state functional MRI(rs-fMRI).Method:A total of 28 patients with HM(10 males and 18 females),18 patients with LM(4 males and 14 females),and 59 healthy controls(27 males and 32 females)were enrolled in this study.The age,sex and education level of the candidates were similar,all of them were right-handed,and all the candidates were scanned by resting state functional magnetic resonance imaging(rs-fMRI).The voxel-level DC method was used to assess spontaneous brain activity.Correlation analysis was used to explore the change of average DC value in different brain regions,in order to analyze differences in brain activity between HM and LM.Result:DC values of the right cerebellum anterior lobe/brainstem,right parahippocampal gyrus,and left caudate in HM patients were significantly higher than those in LM patients(P < 0.05).In contrast,DC values of the left middle frontal gyrus,right inferior frontal gyrus,left medial frontal gyrus,and left inferior parietal lobule were significantly lower in patients with HM(P < 0.05).Conclusion:There are differences in DC values in multiple brain regions between high myopia and low myopia,suggesting that the brain functional network is different between high myopia and low myopia,and there are abnormal changes of brain function.It provides a new Breakthrough for exploring the difference of neural mechanism between high myopia and low myopia,and may provide a new direction for the diagnosis and treatment of high myopia and low myopia.