| Objective: The aim of this study was to investigate the effects of genetic and non-genetic factors on the stable dose of warfarin in Gansu population.Methods : We enrolled 213 patients on stable warfarin anticoagulant therapy with an international normalized ratio maintained between 1.5 and 2.3.Basic characteristics of patients were recorded,Based on PCR,pharmacokinetic and pharmacological genetic polymorphisms of CYP2C9 gene(Cytochrome P450 2C9)and VKORC1 gene(Vitamin K epoxide reductase complex subunit 1-1639)related to drug response to warfarin were analyzed.Results: The dose of warfarin was positively correlated with age(r=0.147,P<0.05),weight(r=0.496,P<0.01)and BMI(r=0.580,P<0.01).There were significant differences in the homeostasis dose of warfarin in patients with CYP2C9*1*1 and CYP2C9*1*3genotypes(P<0.05).There was a significant difference in warfarin homeostasis dose between VKORC1-AA and VKORC1-GA genotypes(P<0.05).Prediction formula:Y=0.012*age+0.159*BMI-0.368*CYP2C9+0.489* VKORC1-2.19.Conclusions: Based on age,BMI,and the differences between the CYP2C9 and VKORC1 genes,we established a prediction model of the appropriate daily dose of warfarin for patients in Gansu province.This administration model may help clinicians administer warfarin more safely and effectively. |
