Correlation Between Plasma Brain Natriuretic Peptide And Functional Outcome After Venous Thrombolysis In Patients With Acute Ischemic Stroke

Objective:To study the correlation between brain natriuretic peptide in plasma and functional outcome in patients with acute ischemic stroke after intravenous thrombolysis and its significance.To explore the correlation between the level of BNP in plasma and the severity of neurological impairment in acute ischemic stroke and its significanceMethods:An analysis was performed on 173 cases of acute ischemic stroke patients with intravenous thrombolysis from March 2014 to July 2018 in our hospital.Outcomes were measured as 3-month modified Rankin Scale score("good outcome"=0-2 vs."poor outcome"=3-6).Multivariate logistic regression was used to assess association between BNP and functional outcomes.Predictive performance of BNP was assessed by ROC curves.Spearman correlation was used to analyze the correlation between plasma BNP and NIHSS scoresResults1.Compared with the good outcome group,the level of BNP in the poor outcome group was significantly increased(p<0.001);Besides,Elevated BNP level(BNP>294pg/ml)was an independent predictor of functional outcome at 3 months in patients with acute ischemic stroke after intravenous thrombolysis(OR=2.908,95%CI=1.130-7.480,p=0.027)According to ROC curve analysis,the elevated BNP level(BNP>294pg/ml)have a certain predictive ability for poor functional outcome 3 months after intravenous thrombolysis in patients with acute ischemic stroke(sensitivity 79.21%,specificity 61.19%,area under the curve 0.720,95%CI=0.645-0.786,p<0.0001);BNP combined with NIHSS score,CRP,D-dimer and blood glucose can increase the predictive power of NIHSS score for poor functional outcome at 3 months after thrombolysis(p=0.0176)2.In the subgroup receiving intravenous thrombolytic therapy alone,the level of BNP in the poor outcome group(mRS?2)was significantly increased(p=0.003).In the subgroup receiving intravenous thrombolysis bridging endovascular intervention,the level of BNP in the poor outcome group(mRS>2)was significantly increased(p=0.049)3.Spearman correlation was used to analyze the correlation between plasma BNP level and NIHSS score on admission,and a certain correlation was found(r=0.428,p<0.05)Conclusions1.Elevated plasma BNP level after thrombolysis was significantly associated with poor functional outcome in patients with acute ischemic stroke after intravenous thrombolysis,suggesting a predictive role of BNP for poor outcome at 3 months after intravenous thrombolysis2.There is a correlation between the level of BNP and the severity of neurological impairment in acute ischemic stroke.