New Method For The Synthesis Of Imide Under Transition-Metal-Free Conditions

The imide moiety is a well-known structural motif in many biologically active natural products,and it also plays an important role in various reactions.Moreover,imide is a key structural motif that widely present in drugs and is a basic component of industrial materials.Therefore,it is very important to find a simple and practical method to synthesize these compounds.Employing N-acylpyrrole and N-acylglutarimide as starting materials,this study prepare various of imides,and the yield up to 90%.In order to explore the generality of the developed acylation method,we further studied the direct acylation of N-acylglutarimide with aromatic esters.To our delight,the reaction worked well with similar reaction conditions and 29 imides were synthesized.In addition,when N-acylglutarimide itself was used as an acylating agent,symmetrical imides can also be prepared successfully.Overall,we developed a practical,simple and efficient method for the synthesis of symmetric and unsymmetric imides.The advantages and importance of this transition-free metal process outlined in this study make it a valuable contribution in the chemistry of imide synthesis.