Research On XFCT Imaging Based On Targeted Nanoparticle Medicine In Mice Model

Cancer is one of the main causes of death;therefore,researchers all around the world is making efforts to find the method of cancer curing.The chance of curing cancer is extremely depending on the period of discovering cancer,the chance of curing will increase significantly while discover the cancer in the early stage.It is important to explore different new diagnose technique to find out cancer in early stage.XFCT(X-ray Fluorescence Computed Tomography)use X-ray to excite the high atomic number elements such as gold or gadolinium that inject into living specimen.It may become one of the early stage diagnosing method in the future.Compared to nuclear medicine diagnose technique such as SPECT or PET,XFCT imaging is using targeted nanoparticle medicine instead of radioactive nuclide,it can significantly decrease the diagnosing cost.The targeted nanoparticle is significantly affect the quality of reconstructed image.This research is using Monte Carlo simulation to investigate whether the size of nanoparticle will affect production of fluorescence photons.The result shows that the result is tiny.Afterwards,this research conduct in-vivo experiment using some gadolinium-contained medicines that are already applying in others Clinical application or scientific research.The in vivo experiment shows that water-soluble Na Gd F4 may apply in XFCT imaging.The reconstructed XFCT images shows the Lung and Liver of the mice that injected Na Gd F4 have fluorescence signal.The reconstructed XFCT images of other gadolinium nanoparticles have no obvious fluorescence signal.It may due to lack of targeted ability.