Correlation Between Anemia And Diabetic Retinopathy In Patients With Type 2 Diabetes

Background and purpose:Diabetic retinopathy is one of the most common and serious microvascular complications of diabetes.Anemia is a common comorbidity in patients with type 2diabetes.Previous studies have mostly focused on the correlation between anemia and diabetic nephropathy.Studies at home and abroad on anemia in diabetic retinopathy less.The purpose of this study was to investigate the relationship between anemia and hemoglobin concentrations and diabetic retinopathy and related metabolic indicators in patients with type 2 diabetes,to improve the clinician's understanding of the risk factors for diabetic retinopathy,and to identify and prevent the disease early.Method:392 patients with type 2 diabetes who were hospitalized in the endocrinology department of China-Japan friendship hospital of Jilin university from March 2019 to October 2019 and had complete clinical data were selected for retrospective study.General data collected include name,sex,age,course of diabetes,smoking history,drinking history,family history of diabetes,history of hypertension,whether lipid-lowering drugs are used,systolic pressure,diastolic pressure,height and weight.The collected laboratory examination indexes include fasting blood glucose,2-hour postprandial blood glucose,glycosylated hemoglobin,triglyceride,total cholesterol,low density lipoprotein cholesterol,high density lipoprotein cholesterol,uric acid,creatinine,microalbuminuria/creatinine,thyrotropin and free thyroxine.SPSS 24.0was used to carry out statistical analysis on the data.Firstly,the data were divided into DR group and NDR group according to the presence or absence of DR,and T test and rank sum test were carried out.Then,the data were divided into DR,NPDR and PDR groups according to the severity of DR,and variance analysis,rank sum test and chi-square test were carried out to analyze the difference of baseline data of patients.After that,single-factor Logistic regression analysis was used to screen out the indicators related to DR.Finally,multi-factor logistic regression analysis was carried out on the continuous variables with the main positive results obtained by the above statistical tests.After controlling the confounding factors such as age and gender,the relationship between anemia,Hb concentration and retinopathy was discussed.P<0.05,the difference was statistically significant.Result:1.The general data and laboratory tests of NDR group,NPDR group and PDR group were analyzed.The differences of hemoglobin concentration,anemia,2h PG,Hb A1 c,FPG,Cr,TC and other indexes of patients were statistically significant.2.Single factor analysis showed that disease course,hypertension,smoking,drinking,anemia,Hb A1 c,ACR,FPG,LDL-C were positively correlated with DR risk.Hb concentration is negatively correlated with DR risk.3.logistic regression analysis shows that Hb is the protective factor for DR,and the risk of DR decreases with the increase of Hb level.The risk of DR in anemic population is 3.243 times higher than that in non-anemic population(OR=3.243,95%CI: 2.768,4.672,P=0.016).4.Spearman correlation analysis showed that Hb concentration was positively correlated with DBP,BMI,TC,FT4,but negatively correlated with age,disease course,ACR,Cr.Conclusion:1.In T2 DM patients,anemia is closely related to the occurrence of DR,and Hb concentration is negatively correlated with DR.With the increase of Hb concentration,the prevalence of DR decreases.2.In clinical diagnosis and treatment work,attention should be paid to the screening of anemia and Hb concentration monitoring of T2 DM patients,timely correcting anemia of T2 DM patients,and screening fundus lesions of T2 DM patients complicated with anemia as soon as possible.