Risk Factors And Clinical Characteristics Of Male Patients With Premature Acute Myocardial Infarction

ObjectivesStudying the risk factors and clinical characteristics of male patients with premature acute myocardial infarction?AMI?.Methods1.A retrospective study was conducted to analyze the clinical data of 406patients who were admitted to the First Hospital of Jilin University from January 2018to June 2018 and underwent coronary angiography.Of which 134 male patients?age<55 years old?with AMI?onset time<24 h?were selected as a case group?Group1?,176?age?55 years old?male patients with AMI were selected as the non-premature AMI group?Group 2?and 96 male patients?age<55 years old?with non-coronary artery disease excluded by coronary angiography?Group 3?who were hospitalized during the same period.2.Risk factors including hypertension,type 2 diabetes,dyslipidemia,smoking and family history were collected.Fasting blood glucose,uric acid,albumin,TG,TC,LDL-C,HDL-C,non-HDL-C,Killip grading and other basic information were collected upon admission.Risk factors of male patients with premature AMI and multivessel disease were analyzed.3.The Coronary angiographic characteristics observed by coronary angiography were collected.Compare the differences of the number,diffuse lesions and collateral circulation between the Group1 and Group2.4.Collect the occurrence of major adverse cardiovascular events in hospital.5.All data were analyzed by SPSS 23.0 statistical software.The normal distribution of the measurement data was expressed as mean±standard deviation?`c±s?.t test was used for comparison between groups?The skewed distribution was represented by median and quartile M(Q₂₅,Q₇₅),Mann-whitney U test was used for comparison between the two groups.Count data were expressed by frequency?percentage?,the X2test or Fisher's test was used for comparison between groups.Logistic regression analysis was used to find the risk factors of premature AMI and multivessel disease.The difference was statistically significant at P<0.05.Results1.Compared with the Group 3,prevalence of smoking,diabetes,dyslipidemia,TG,TC,LDL-C and non-HDL-C in the Group 1 was higher?P<0.05?.Compared with the Group 2,Group 1 had higher prevalence of smoking,dyslipidemia,family history of coronary heart disease,and higher level of uric acid,glutamyl-transferase,TG,TC,LDL-C and non-HDL-C.The prevalence of hypertension was lower in Group 1?P<0.05?.2.Logistic regression analysis showed that diabetes?OR=2.567?,non-HDL-C?0R=2.010?and smoking?OR=1.894?were the independent risk factors associated with male premature AMI.3.Compared with the single-vessel lesion group,the proportion of the three-vessel lesion combined with diabetes and hypertension was more and the HDL-C level was lower?P<0.05?.4.Logistic regression analysis showed that diabetes?OR=3.837?was the independent risk factors associated with male premature AMI multivessel disease.HDL-C?OR=0.104?was a protective factor.5.Compared with the Group 2,the proportion of single-branch lesions in the Group 1 was higher,while the proportion of double-branch lesions,multivessel lesions and diffuse lesions were lower?P<0.05?.6.Compared with the Group 2,the overall incidence of MACE during hospitalization in the Group 1 was lower?P<0.05?.Conclusions1.The risk factors for male patients with premature AMI are mainly dyslipidemia diabetes and smoking.The independent risk factors are diabetes,smoking and non-HDL-C.In addition,there may be other undefined risk factors.2.Diabetes is independent risk factors for male patients with premature AMI multivessel disease.HDL-C?OR=0.104?was a protective factor.3.The coronary artery lesions of male patients with premature AMI are mainly single branch,diffuse lesions are rare.4?The overall incidence of MACE during hospitalization in the male patients with premature AMI was lower than older.