Voxel-based Morphometry On Grey Matter Volume Of The Adolescent And Young Adult With Major Depressive Disorder

Object: Based on 3.0 T MRI t1 images,voxel-based morphometry method(VBM)is used to analyze the volume changes of gray matter in adolescent and young adult with major depressive disorder(MDD)and investigate cerebral nerve biomarkers of adolescent and young adult with MDD.Method: We recruited 53 adolescents and young adults with MDD and47 healthy controls.All subjects were scanned by 3.0T MRI.VBM was applied to compare brain volume differences between the two groups.VBM analyses to investigate voxel-wise differences of the gray matter between groups were performed using permutation-based non-parametric testing(5000 permutations),implemented using Randomise.A statistical threshold of p <0.05 after Threshold-free cluster enhancement(TFCE)for multiple comparisons was used.Results: The present study revealed a cluster of reduced grey matter volume in MDD group,located in the inferior parietal lobule(IPL)—an area corresponding to BA 40(left supramarginal gyrus),MNI peak coordinates x=-48,y=-26,z=34;voxels=155;p <0.05.Conclusions: Compare to healthy controls,the volume of gray matter in left supramarginal gyrus was decreased in adolescent and young adult withdepression,decreased gray matter volume in left supramarginal gyrus may be a potential neurobiological diathesis in adolescent and young adult with major depressive disorder.