The Influence Of Nonalcoholic Fatty Liver Disease On The Course Of Acute Pancreatitis

Background and purpose:Fatty liver is a very common chronic liver disease in China.The occurrence of fatty liver is related to long-term drinking,insulin resistance and dyslipidemia^[1].According to the causes of the disease,it can be divided into alcoholic fatty liver disease and nonalcoholic fatty liver disease（NAFLD）.Incidence rate of NFLD incidence is increasing year by year in China,with the improvement of living standard and the change of diet structure.The incidence rate of NFLD in China is higher,and the incidence rate is 20.39%-47.98%^[2-5].As is reported that the prevalence in obese children is 53.72%^[6],In recent years,there are more and more reports about acute fatty liver in pregnancy.Nonalcoholic fatty liver can be accompanied by many other diseases,such as blood glucose disorder,dyslipidemia,hypertension,atherosclerosis,hyperuricemia and other diseases^[8-9].In recent years,NFLD has been found to be related to the occurrence of acute pancreatitis（AP）^[10-11].The incidence rate of AP worldwide is about 13⁴5（/10）million,ranking first among the causes of many diseases leading to digestive diseases,and the incidence rate is increasing year by year[12].The mortality rate of AP can reach 5%-10%,and that of severe pancreatitis is as high as 25%-30%.According to the literature,20%of patients with acute pancreatitis will progress to severe acute pancreatitis^[13].So it is very important to accurately evaluate the condition of AP patients.In this study,the image information provided by CT scan and the clinical data of patients were analyzed retrospectively.To investigate the effect of nonalcoholic fatty liver on the progression of acute pancreatitis.Methods:The imaging data and clinical data of patients were retrospectively analyzed.SPSS23.0 was used for statistical analysis.Result:The weight,serum amylase and serum lipase of the patients in the non-alcoholic fatty liver group were higher than those in the general pancreatitis group（P<0.05）.Conclusion:（1）Patients with nonalcoholic fatty liver disease are more likely to develop acute pancreatitis than those without fatty liver disease.（2）Acute inflammation of non-alcoholic fatty liver is more serious.（3）It was found that patients with nonalcoholic fatty liver disease were more likely to develop severe pancreatitis.（4）nonalcoholic fatty liver leads to local complications,persistent organ failure and increased mortality in patients with acute pancreatitis.