Compared Study On Ultrasonic Characteristics And Pathological Findings Of Rabbit Liver After Administration Of Chemotherapeutants And Endocriminal Medication

Objective:To observe and study the ultrasonic characteristics and pathological findings of rabbit liver after administration of chemotherapeutants and endocriminal medicine,with a focus on fatty liver disease.Methods:40 female Newzaland rabbits were randomly divided into 4 groups,group A(standard diet+starch),group B(high-fat diet),group C(epirubicine + cyclophosphamide + tamoxifen +standard diet),group D(epirubicine+cyclophosphamide+tamoxifen+high-fat diet),10 in each group.Before administration of medication hepatic function,serum fat,conventional ultrasound,shear wave velocity of hepatic parenchyma were executed.After 6-month feeding for group A and group B,and after 6-cycle chemotherapy followed by 3-month tamoxifen above-mentioned examinations were carried out again.Finally rabbit liver pathology was performed.Results:Laboratory: AST and ALT in group A showed no statistical difference before and after administration of medication,AST in groups B,C and D were elevated after administration of medication.The values of groups C and D were higher than that of group B.There was no statistical difference between group C and group D.ALT in groups B,C and D were elevated after administration of medication.The values of groups C and D were higher than that of group B.The value of group D was higher than that of group C.TC and TG in groups B,C and D were elevated after the administration of medication.The values of TC and TG in groups B and D were higher than group C,the value of group D was higher than that of group B.Ultrasound :There was no different ultrasonic characteristics in group A before and after administration of medication.Group B showed mild enlargement of the hepatic size,enhanced and dense parenchymal echoes after medication.Group C showed normal liver size,but somewhat unsmooth capsule,lightly enhanced and heterogenous panrenchymal echoes.Group D showed obvious and dense echogenicity in liver parenchyma besides group C's characteristics.The shear-wave velocity of groups B,C,D elevated after administration of medication.Pathology :Group B showed moderate to severe steatosis,mild to moderate hydropic swelling.Group C showed mild steatosis,moderate to severe hydropic swelling,local cholestasis and blood stasis,mild to moderate inflammation cell infiltration,focal fibrosis.Group D showed moderate to severe steatosis,moderate to severe hydropic swelling,local cholestasis and blood stasis,mild to severe inflammation cell infiltration,focal fibrosis and some regenerative nodules.Conclusion:Although the rabbits which only recieved the chemotherapy and tamoxifen showed some steatosis besides hepatic celullar and parenchymal lesions,they did not showed ultrasonographically remarkable fatty liver sonogram,however those rabbits which recieved high-fat diet or chemotherapy+tamoxifen+high-fat diet showed obvious fatty-liver sonographic characteristics.The fact demonstrates that high-fat diet play a key role in forming fatty liver.Acoustic radiation force impulse imaging(ARFI)has some values in evaluating the hepatic lesions after the administration of chemotherapy and endocrine medication or high-fat diet.