Effects Of One-lung Ventilation On Claudin-4 And Intrapulmonary Shut Rate In Patients

Objective:To investigate the changes of intrapulmonary shunt rate and claudin-4 protein during one-lung ventilation for esophageal cancer surgery.Methods:Thirty patients who planned to undergo thoracoscopic and laparoscopic esophagectomy for esophageal cancer in our hospital were chosen.Blood samples from radial artery and internal jugular vein were collected:10 min（T₀）before OLV in lateral decubitus position（LDP）,60 min after OLV in LDP（T₁）,60 min（T₂）after resumption of TLV.Results:Intrapulmonary shunt rate was significantly higher at T₁ than at T₀（P<0.05）,T₁ was higher than T₂（P<0.05）,and there was no significant difference between T₀ and T₂（P>0.05）;Claudin-4 was higher at T₁,T₂ than at T₀（P<0.05）,but there was no significant difference between T₁ and T₂（P>0.05）.Conclusion:One-lung ventilation can lead to significant intrapulmonary shunt,and it can be improved after the recovery of two-lung ventilation,while claudin-4 can be up-regulated,which plays a certain role in lung protection.