Meta-analysis Of The Correlation Between Human Papillomavirus Infection And Domestic Laryngeal Squamous Cell Carcinoma

Objective:To comprehensively evaluate the prevalence of Human Papillomavirus(HPV)positive expression in patients with Laryngeal Squamous Cell Carcinoma(LSCC).Methods:A comprehensive and systematic search of each database using a computer,collection of documents based on inclusion and exclusion criteria,and meta-analysis of the extracted data using Stata14.0 statistical software: analysis of the overall data collected,with regional factors,patient gender,HPV classification(high risk and low risk),smoking history,drinking history,clinical features of cancer(differentiation,primary site and stage of cancer)were subgroup analysis,and the results of subgroup analysis were analyzed using Revman 5.3 statistical software.Finally We will obtain HPV infection in domestic laryngeal cancer patients.Results:A total of 13 articles were included.The total positive rate of HPV in domestic laryngeal cancer patients was 12%(95% CI: 9% to 15%).Subgroup analysis results: HPV positive rate in patients with northern laryngeal cancer [12%(95% CI: 7% to 17%)] HPV positive rate in patients with southern laryngeal cancer [13%(95% CI: 9% to 17%)],HPV positive rate in female patients with laryngeal cancer [26%(95% CI: 3% to 55%)] and HPV positive rate in male patients with laryngeal cancer [11%(95% CI: 7% to 15%)],moderately and moderately differentiated HPV positive rate in patients with laryngeal cancer [15%(95% CI: 8% to 21%)] and HPV positive rate in patients with highly differentiated laryngeal cancer [9%(95% CI: 6% to 13%)],glottic type HPV positive rate of laryngeal cancer [(10%(95% CI: 6% to 3%)] and HPV positive rate of patients with non-glottic laryngeal cancer [(13%(95% CI: 7% to 19%)],HPV positive rate in patients with stage 1+2 laryngeal cancer [16%(95% CI: 10% to 21%)] and HPV positive rate in patients with stage 3+4 laryngeal cancer [17%(95% CI: 10% to 25%)],There was no statistically significant difference between the groups.High-risk HPV positive rate in patients with laryngeal cancer [10%(95% CI: 7% ~ 13%)]is higher than the low-risk HPV positive rate [3%(95% CI: 1% ~ 4%)],The difference between groups was statistically significant(P<0.00001);HPV positive rate in patients with laryngeal cancer without smoking history [19%(95% CI: 12% to 26%)] is higher than the rate in patients with smoking history of laryngeal cancer [7%(95% CI: 2% to 12%)],the difference was statistically significant(P=0.004);HPV positive rate in patients with laryngeal cancer without drinking history [12%(95% CI: 9% to 16%)]is higher than the rate in patients with laryngeal cancer who had a history of drinking [ 5%(95% CI: 3% to 8%)],the difference was statistically significant(P=0.001).Conclusion:In this study,the relationship between HPV and the basic characteristics of laryngeal cancer patients was further clarified by meta-analysis of the HPV positive rate of laryngeal cancer patients in China: there was a low HPV positive expression in domestic laryngeal cancer patients,and the high-risk HPV positive rate was higher than the rate in the patients with laryngeal cancer who have a low-risk type.The patients with laryngeal cancer who have no history of smoking or drinking have a higher HPV positive rate.The results of this study have certain reference value for understanding the analysis of risk factors for laryngeal cancer in China,and can be used to guide individualized treatment options for patients with HPV positive laryngeal cancer.