Efficacy Of ? Blockers For COPD Combined With CVD:Meta Analysis

Objective:To assess the effect of ? blockers on pulmonary function,exacerbation and mortality in patients with chronic obstructive pulmonary disease(COPD)complicated with Cardiovascular Disease(CVD).Methods:Develop inclusion criteria and retrieval strategies.We use computer to retrieval of foreign language databases such as PUBMED(1945-2019.10),MEDLINE(1966-2019.10)as well as CNKI(1979-2019.10),WANGFANG(1998-2019.10)and other Chinese databases,etc.To collect and study the related literature on pulmonary function changes,acute aggravation and mortality in patients with COPD complicated with CVD treated with ? receptor blockers.Then Meta analysis is carried out by using STATA 12.0 software.Results:1.Results of Literature Retrieval:Preliminary retrieval of 4733 literature,after exclusion of repetition,reading of the title,abstract and full text content step by step screening,the final inclusion of 34 literature.Among them,English literature 18,Chinese literature 16;randomized controlled study 17,retrospective cohort study 17;sample size 1,415,791.2.The results of Meta analysis showed that ? blocker had no significant effect on pulmonary function in patients with COPD.The difference between FEV1%,FEV1/FVC and control group before and after treatment was WMD and its 95%CI were 0.97(0.10,1.84),-0.14(-1.47,1.18).? blocker could significantly reduce mortality(OR=0.65,95%CI=0.51-0.83).And acute aggravated readmission rate(OR=-0.64,95%CI=0.43-0.97).Conclusion:? blockers have no effect on pulmonary function of COPD complicated with CVD,which can not only decrease the risk of overall mortality but also reduce the risk of exacerbation of COPD.