The Effect Of DBS On Peripheral Immune System In Parkinson's Disease

Objective:The aim of this study was to observe the effects of subthalamic nucleus deep brain stimulation(STN-DBS)on the peripheral immune system in patients with Parkinson's disease(PD).Methods:We recruited 27 idiopathic PD patients from The General Hospital of the People's Liberation Army(PLAGH).Of those,11 underwent STN-DBS(PD-ST)at a minimum of six months ago,16 patients were surgery-na?ve(PD-SN),and 11 were healthy controls(HC).The proportion of T lymphocyte subsets in peripheral venous blood was measured by flow cytometry.Hoehn-Yahr stage(H-Y)and Unified Parkinson's Disease Rating Scale(UPDRS)were used to measure symptom severity.Results:The duration of PD-ST was significantly longer than PD-SN [(12.55±3.93)years,(7.69±3.77)years,P=0.005].There was no significant difference in the total score of UPDRS [(74.46±21.94),(71.27±24.89),P=0.742].The proportions of Th1 and Th17 in PD-ST were significantly lower than in PD-SN.The proportion of Th1 was[(9.40±6.43)%,(17.43±11.35)%,P=0.026],and the proportion of Th17 was[(4.36±1.32)%,(11.84±8.43)%,P=0.002].The proportion of Treg cells in PD-ST was higher than in PD-SN [(5.20±1.17)%,(2.61±1.93)%,P=0.005].Conclusion:STN-DBS relieves clinical symptoms of PD and alleviates the inflammatory differentiation bias of peripheral T lymphocytes,while inhibiting excessive inflammatory response in the peripheral immune system.