Diagnostic Value Of Serum Amyloid A Combined With Hs-CRP Detection In Bronchiolitis

Objective The SAA and hs-CRP levels and changes of children with bronchiolitis were detected in combination to provide scientific basis for the diagnosis and evaluation of efficacy of bronchiolitis with bacterial infection.Method From January 2019 to January 2020,102 cases of bronchiolitis and 100 cases of bacterial pneumonia in Ningxia Hui Autonomous Region People's Hospital.Fasting venous blood was extracted from two groups on the first and fifth days of admission 2ml,and SAA was detected by latex immunoturbidimetry.The SAA and hs-CRP levels of bronchiolitis group and bacterial pneumonia group were measured on the first day of admission and 5 days after treatment.The SAA?hs-CRP and SAA/hs-CRP ratio in two groups were statistically analyzed by SPSS 19.0.Result 1.The SAA of children in bronchiolitis group and bacterial pneumonia group increased significantly at the time of admission,the difference between the two groups was statistically significant(P<0.05);the SAA of the two groups decreased significantly after 5 days of treatment,and the difference between the SAA of the 5th day and the 1st day was significant(P<0.05).2.The hs-CRP in bronchiolitis group was not significantly increased on admission,hs-CRP in bacterial pneumonia group was significantly increased,the difference between the two groups was statistically significant(P<0.05);There was no significant difference in hs-CRP of bronchiolitis group compared with the hs-CRP of admission after 5 days of treatment(P>0.05);The hs-CRP of 5 days of treatment in bacterial pneumonia group was hs-CRP lower than that at admission,the difference was statistically significant(P<0.05);3.ROC curve analysis of SAA?hs-CRP and SAA/hs-CRP for the diagnosis of bronchiolitis: SAA detection concentration of the cut-off is 56.12 mg/L,sensitivity of 99%,specificity of 65%(AUC=0.837,P=0.00 P<0.05);The hs-CRP detection concentration of cut-off is 1.79mg/L,sensitivity of 85.1%,specificity of 31.7%(AUC=0.38,P=0.003 P<0.05);SAA/hs-CRP of cut-off is 20.3,sensitivity of 99%,specificity of 88.1%(AUC=0.945 P=0.00 P<0.05).Conclusion 1.The serum SAA level of children with bronchiolitis increased,the hs-CRP increase was not obvious,and the SAA/hs-CRP ratio increased obviously.The combined detection of the two can help to judge whether bronchiolitis is complicated with bacterial infection in the early stage and guide the rational use of antibiotics.2.The combined detection of SAA and hs-CRP can evaluate the therapeutic effect,among which,the SAA/hs-CRP ratio is more instructive to judge whether bronchiolitis is associated with bacterial infection.