The Epidemiological Characteristics Of Hand-foot-and-mouth Disease In Chuzhou City,Anhui Province From The Year Of 2012 To 2015

Objectives1.To explore the epidemiological characteristics of hand-foot-and-mouth disease(HFMD)in Chuzhou city,Anhui province from the year of 2012 to 2015 and to describe the distributions of HFMD including who develop the disease,and where and when the disease occurs.We aimed to provide evidence for the disease prevention and control.2.To detect the enteropathogensand to determine the main enterovirus in the HFMD of determine,this will contribute to evidence for reducing the severe patients and reducing the number of deaths.Methods1.Data of HFMD were enrolled form the disease monitoring information report system of Chuzhou Center for Disease Control and Prevention.The distributions of HFMD in the Chuzhou city from 2012 to 2015 were analyzed using the descriptive epidemiology methods including morbidity and the disease severity.2.The pathogenes of enterovirus were detected using Real-time PCR.Data summarization and plotting of HFMD were using Excel 2010 software and Graphpad5.1 software,respectively.The comparison of qualitative data were analyzed using chi-square test in SPSS 11.0 software,and the P-values less than 0.05 were considered as the differences were statistically significant.Results1.General situation of the HFMD: During 2012 to 2015,a total of 31717 HFMD patients were enrolled(the incidence was 98.85/100000 individuals)in this study,including 355 severe patients(the rate was 1.12%)and 5 deaths(the mortality rate was0.02/100000 individuals).2.Geographic distribution: During 2012 to 2015,two districts and six counties in Chuzhou city had HFMD patients in each year.In addition,several patients were death in the county of Fengyang and Dingyuan,and the number of patients and death were maximum in Fengyang county,while the morbidity and mortality were highest in Dingyuan county,the number and rate of severe patients were highest in Mingguang county.These differences in various areas had statistical significance(P<0.05).3.Distribution of time: The number of patients were maximum in the year of 2014 and this year had 11505 patients.The number of patients and severe patients showed bimodal distribution in the month of each year.These differences were statistical significance between every month(P<0.05).4.Population distribution: The incidence of individuals of HFMD were under the 5aged-scattered children and these patients were mainly male.These differences had statistical significance(P<0.05).5.Pathogenic characteristics: A total of 814 HFMD patients were detected using RT-PCR.Of these 814 patients,most of the HFMD cases were suffer from enterovirus type 71(EV71)and Coxsackie virus 16 type of group A(Cox A16)infection.These differences had statistical significance in the distribution of enterovirus(P<0.05).ConclusionThere are obvious HFMD distribution characteristics of population,season and region in Chuzhou city,and the EV71 and Cox A16 is the main cause of HFMD disease in the city.It is important to do well in surveillance,propaganda and education and for disease prevention and control.