Prognostic Significance Of Additional Chromosomal Aberrations In T(8;21)acute Myeloid Leukemia: A Meta-analysis

Objective: To examine the prognostic significance of additional chromosomal aberrations in t(8;21)acute myeloid leukemia.Method: In order to gain all the reference published from January 1st,1973 to December 31,2018,we conducted a literature search in different databases,including PubMed,China National Knowledge Internet,Embase,China Biology Medicine disc,Cochrane Library,Web of Science,Wanfang database and Weipu database.We adopted complete remission(CR)rate,relapse rate(RR),3-year survival rate and overall survival(OS)as result indicators.Statistical analyses were performed using Rev Man 5.3.Results: 13 studies were included.In all t(8;21)AML patients,the risk ratio(RR)for CR rate was 0.92(95%CI: 0.85-0.99;P=0.03),the RR for 3-year survival rate was 0.40(95%CI: 0.29-0.57;P<0.00001),indicating that additional chromosomal aberrations negatively impacted on CR rate,3-year survival rate in t(8;21)AML patients;the hazard ratio(HR)for OS was 1.17(95%CI: 0.88-1.56;P=0.28),the risk ratio(RR)for relapse rate(RR)was 1.47(95%CI: 0.84-2.57;P=0.17),there was no statistically difference between t(8;21)AML with other additional chromosomal aberrations and sole t(8;21)AML patients in OS and relapse rate(RR);the risk ratio(RR)for CR rate was 0.90(95%CI: 0.79-1.02;P=0.10),there was no statistically difference between t(8;21)AML with sex chromosome loss and sole t(8;21)AML patients in CR rate.Conclusion: Additional chromosomal aberrations is an adverse prognostic factor in complete remission rate,3-year survival rate in t(8;21)AML patients,but no obvious differences in relapse rate and overall survival have been observed between t(8;21)AML with other additional chromosomal aberrations and sole t(8;21)AML patients;there was no obvious difference between t(8;21)AML with sex chromosome loss and sole t(8;21)AML patients in complete remission rate.