The Correlation Between Obstructive Sleep Hypopnea Syndrome And Peripheral Airway Resistance In Qinghai Province

Objectives: According to the lung function of patients with OSAHS,the correlation between OSAHS and peripheral airway resistance was explored.Methods: This was a cross-sectional study conducted in respiratory department of affiliated hospital of Qinghai university from August 2017 to August 2019.Adult patients who lived in Qinghai Province,were diagnosed with OSAHS were enrolled.According to apne-hypopnea index(AHI),patients were divided into three groups: mild group(5≤AHI≤15),moderate group(15<AHI≤30),and severe group(AHI>30).Spearman correlation analysis was used to explore the correlation between AHI and R5-R20.The multivariable linear regression models were used to study the relationship between severity of OSAHS and R5-R20.Logistic regression models were used to study the relationship between OSAHS and chronic bronchitis and small-airway diseases.In addition,subgroup analyses were conducted based on sex and chronic obstructive pulmonary disease(COPD)to further explore the relationship between severity of OSAHS and R5-R20.Results: A total of 184 adult patients diagnosed with OSAHS were included in this study.Spearman correlation analysis showed that the R5-R20 increased with the elevation of AHI(r=0.402,P<0.001).Multivariable linear regression analysis showed that every degree of OSAHS severity increased,R5-R20 increased(β,0.340,95% CI,0.199-0.481,P<0.001).After that,the results of subgroup analysis showed that the relationship between OSAHS severity and R5-R20 still exists in females and males(females: β,0.517;95% CI,0.207-0.827,P= 0.002;Male: β,0.309;95% CI,0.144-0.474,P<0.001),or in non-COPD group and COPD group(non-COPD: β,0.262,95% CI,0.113-0.410,P=0.001;COPD: β,0.497,95% CI,0.154-0.840,P=0.005).Subsequently,this study found that the severity of OSAHS was correlated with the occurrence of chronic bronchitis(11.4% vs.17.0% vs.29.9%,P=0.032).After adjusting for multiple covariates,the relationship still exists,that is,the risk of the prevalence of chronic bronchitis in patients with severe OSAHS is higher than that in patients with mild OSAHS(OR,3.181;95% CI,1.063-9.517,P=0.039).Furthermore,this study found that OSAHS severity was also correlated with small-airway disease(38.6% vs.43.4% vs.81.6%,P<0.001).After adjusting for multiple covariates,the risk of the prevalence of small airway disease in patients with severe OSAHS was still higher than that of patients with mild OSAHS(OR,4.878;95% CI,1.983-12.002,P =0.001).Conclusions: Severity of OSAHS is related to peripheral airway resistance and small airway disease.Patients in higher degree of OSAHS severity had higher peripheral airway resistance and the risk of the prevalence of chronic bronchitis and small airway disease.