Meta-analysis Of Vitamin E In The Prevention Of Contrast-induced Nephropathy

Objective:To evaluate the effect of vitamin E on the prevention of contrast-induced nep hropathy(CIN)after coronary angiography by meta-analysis.Methods:PubMed,Science,The Cochrane Library and CNKI databases were retrieved from The time of establishment to October 2019.Eligible randomized controlled s tudies(RCTS)were selected according to inclusion criteria and exclusion criteria and data were extracted.The RevMan 5.3 statistical software was used for meta-a nalysis of the article.Results:A total of 829 patients were included in 5 RCTS,including 413 cases in the experimental group(vitamin E combined hydration group)and 416 cases in the control group(hydration alone).The prevalence of CIN in the experimental group and the control group was 5.6% and 14.9% respectively.The prevalence of CIN in the experimental group was significantly lower than that in the control group(RR:0.38,95%CL(0.24,0.60)).In addition,vitamin E decreased serum creatinine(SCr)elevation after contrast administration(standardized mean difference [SMD],-0.27;95%CI,-0.49,-0.06;P = 0.010).However,there was no significant difference in glomerular filtration rate(GFR)between the vitamin E group and the control group(SMD,0.21;95%CI,-0.01,0.43;P = 0.060).Conclusion:Compared with hydration alone,the hydration of vitamin E significantly reduced the incidence of CIN after coronary angiography.