Meta-analysis Of Hypoxia-inducible Factors In The Treatment Of Renal Anemia

Objective:To evaluate the efficacy of hypoxia-inducible factor in the treatment of renal anemia.Methods:PubMed,EMbase,Cochrane,Medline,Google academic,wanfang medicine,cnki,and Chinese biomedicine were searched by computer using the method of Cochrane systematic evaluation.The retrieval time was up to October 2018,and randomized controlled trials(RCTS)of Chinese and English hypoxia-inducing factor drugs for renal anemia were included.Results:A total of 5 RCTS were included,including 418 patients with renal anemia.There was statistical heterogeneity between the studies.(I~2=63%,P<0.00001),Therefore,the random effect model was adopted for combined analysis,The results show that,Compared with the control group,hypoxia-inducible factor can effectively increase hemoglobin(MD=1.66g/dL,95%CI:1.27~2.04,P<0.00001,I~2=63%),transferrin(MD=0.52g/dL,95%CI:0.35~0.69,P<0.00001,I~2=86%),and total iron binding force(MD=9.94 g/dL,95%CI:6.08~13.80,P<0.00001,I~2=92%),reduced ferritin(MD=-59.54μg/L,95%CI:-82.77~-36.31,P<0.00001,I~2=54%),and the element of iron(MD=-34.21μg/L,95%CI:-41.96~-26.46,P<0.00001,I~2=57%).Conclusion:Hypoxic inducing factor can promote or stabilize the hemoglobin level in patients with renal anemia,which is effective in the treatment of anemia.It can obviously reduce the level of iron regulator,regulate iron metabolism and improve the incidence of inflammatory anemia.At the same time,by reducing ferritin content,increasing the level of transferrin and total iron binding force,iron utilization rate was improved.However,short treatment and follow-up period,few drugs included,small number of randomized controlled trials and small total sample size in the included literatures may lead to the deviation of the results in the literatures.Therefore,the efficacy of hypoxia-induced factor in the treatment of renal anemia still needs to be evaluated by more prospective large sample multicenter clinical randomized controlled trials.