The Research Of The Prevalence Of Unruptured Intracranial Aneurysms In Patients With Pituitary Adenomas

Objectives: The objective of this study was to evaluate the association between asymptomatic unruptured intracranial aneurysms(IA)and pituitary adenomas(PA)in Chinese people.We also focused on comparing pituitary growth hormone(GH)adenoma patients with general population to study the situation of pituitary GH adenoma patients coexisted with IA,and analyzed whether the morbidity of IA was affected by age,sex,cavernous sinus invasion and other endocrine or clinical factorsMethods: The prevalence of pituitary adenomas coexisted with unruptured intracranial aneurysms in this research,434 newly diagnosed PA patients and 252 controls from the general population who underwent brain computed tomographic angiography(CTA)examination was included.The incidence of IA and the location of IA in PA patients were compared with those in controls.The PA patients with IA were compared with the patients without IA to identify the risk factors for increased prevalence of IA.Since other researchers have found that among all pituitary adenomas with different classification,the morbidity of intracranial aneurysms coexisted with pituitary growth hormone adenomas are significantly higher than that of other classification,All the population were examined by CTA to compare the morbidity of IA between the two groups.Then we analyzed the independent risk factors affecting the prevalence of IA.Results:The coexistence of PA and IA was found in 36 patients(8.3%),while IA were found in only 2.4% of the general controls,resulting in a significant difference.After stratifying by age,the prevalence of IA among the patients with PA was still higher than that among the general controls in the 5th decade(P = 0.023)and 6th decade(0.035).Most IA(69.8%)was located in the internal carotid artery,and the location of the IA did not differ between the PA patients and the general population.The stepwise multivariate logistic regression indicated that age(P= 0.004)and cavernous sinus invasion(P= 0.022)were related to an increased prevalence of IA in PA patients.The prevalence of pituitary GH adenoma in female patients with intracranial aneurysms was significantly higher than the controls(P=0.007).Conclusions: The PA Patients have an increased prevalence of IA than age-matched controls.An older age and cavernous sinus invasion might be correlated with the increased prevalence of IA in Chinese PA patients.