A Clinical Study On Compound Shelong Capsules In Treating Idiopathic Membranous Nephropathy(Syndrome Of Stagnant Dampness-heat)

Objective:To explore the clinical efficacy of Compound Shelong Capsules in the treatment of idiopathic membranous nephropathy(consistency of phlegm and blood stasis syndrome),and to provide efficacy and safety basis for the treatment of idiopathic membranous nephropathy(dampness and phlegm obstruction syndrome).Methods:Develop diagnostic criteria,inclusion criteria,and exclusion criteria for clinical studies.Patients with pathological diagnosis of membranous nephropathy were collected,and TCM syndrome differentiation was due to phlegm and blood stasis syndrome.The prospective,randomized,double-simulation,parallel-controlled method was used to randomly divide the selected patients into two groups: the experimental group and the control group.The experimental group: basic treatment + Compound Shelong Capsules +compound nephritis tablet mimic;Group plan: basic treatment + compound nephritis tablets + Compound Shelong Capsules simulant.There were 75 cases in each group,a total of 150 cases,both groups were treated for 2 courses,each course of 12 weeks,a total of 24 weeks,before treatment,12 weeks of treatment,24 weeks of treatment for efficacy evaluation,to determine its safety,laboratory indicators and clinical Comprehensive curative effect was used to analyze the curative effect of Compound Shelong Capsules in the treatment of idiopathic membranous nephropathy.Results: The safety,laboratory efficacy and clinical comprehensive efficacy of the two groups were compared on before treatment,12 weeks of treatment,24 weeks of treatment,respectively.1)Safety indicators: blood routine,liver function(AST,ALT),renal function(Cr,BUN),the time points before and after treatment in each group,there was no statistical difference between the indicators,the experimental group and the control group were not obvious to the patients.toxic side effect.2)Laboratory indicators: urine routine,plasma albumin(ALB),urine protein quantitation,serum total cholesterol(TCH),triglyceride(TG),high-density lipoprotein(HDL-C),low-density lipoprotein(LDL)-C),the comparison of time points before and after treatment in each group,the statistical difference between the laboratory indicators before and after treatment.3)Comprehensiveclinical efficacy of traditional Chinese and Western medicine: The clinical curative effect follows the "Guidelines for Clinical Research of New Drugs of Traditional Chinese Medicine" drawn up in 2002 edition.Before treatment,12 weeks and 24 weeks after treatment were compared.At the 12 th week of treatment,the cure rate of Western medicine standard test group was 64.70%,the control group was 57.57%,and the TCM standard test group was69.12%,the cure rate was 53.02%.At the 24 th week of treatment,the Western medicine standard test group was 79.41%,the control group was 65.15%,the TCM standard test group was 80.88%,and the control group was 59.08%.Conclusion: Short-term treatment of Compound Shelong Capsules has good safety to patients,no obvious side effects of heart,liver and kidney toxicity,which can significantly reduce proteinuria and increase plasma albumin content.Compared with the clinical efficacy of Chinese and Western medicine,Fufang Xiaolong Capsule has better curative effect on idiopathic membranous nephropathy.