The Associations Of Serum Uric Acid And All-cause Mortality In Peritoneal Dialysis Patients

Objective:This study was investigate whether baseline uric acid?UA?is an in dependent predictor of all-cause mortality in chronic renal failure patients?CRF?with peritoneal dialysis?PD?.Methods:A retrospective cohort study was designed.A total of 140 patients o nstable continuous ambulatory peritoneal dialysis?CAPD?treatment for more th an 3 months were collected and follow up at First affiliated hospital ofXiamen University Peritoneal Dialysis Center during the January 1^st,2001 to the Dece mber 31^st,2017.All demographic and laboratory data were recorded at baseline.The subjects were divided into three groups based on the tertile of UA valu?M1:UA<387umol/L,M2:UA387⁵19umol/L,M3:UA>519umol/L?.Multiv ariate Cox regression and Kaplan-Meier method was used to calculate the haza rd ratio?HR?of all-cause mortality.Results:A total of 140 CAPD patients were enrolled in this study,including 63 cases of male?45%?,77 cases of female?55%?.The average age was 57?ra nge:44-65?years.The median follow-up time was 31.9?IQR:19.6,66.0?month s.The average UA of all participants was 450.1±146.1 umol/L.No significant differences of baseline characteristics between patients with Age,sex ratio,bod y mass index,duration of dialysis,proportion of patients with hypertension,dia betes mellitus and cardiovascular diseases.Compared to M1 group,the levels o f serum creatinine,urea nitrogen,blood phosphorus and blood potassium were higher in M3 group?P<0.05?.Univariate COX regression analysis suggested a positive correlation between all-cause mortality and baseline uric acid?UA H R=1.04,95%CI:1.00-1.08,P=0.048?.Multivariate COX regression analysis show ed that increased baseline UA was an independent risk factor for all-cause mor tality in PD patients?HR=1.04,95%CI:1.00-1.09,p=0.032?.Conclusions:UA was positively correlated with all-cause mortality in patients undergoing maintenance peritoneal dialysis.The increase of baseline UA elevati on was an independent risk factor for all-cause mortality in those patients.The control of UA level may be helpful to prolong the survival time of patients wi th Peritoneal Dialysis.