The Clinical Characteristics And Influence Factors Of The Inpatients With Ascending Aorta Dilation

Objectives Retrospectively analyzed the clinical characteristics and influence factors of the inpatients with ascending aorta dilation.Methods Data of 719 patients undergoing echocardiography were collected in this retrospective study from January 2017 to December 2018 in Fujian Medical University of Union Hospital.According to whether the ascending aorta dilation or not(male > 34 mm,female > 31mm),the inpatients were categorised into the ascending aortic dilatation group and the control group,and the clinical features between the two groups were compared.Multivariate logistic regression analysis was done to determine the influence factors of ascending aortic dilatation.The pulse pressure was divided into three subgroups(20mm Hg≤PP≤39mm Hg,40≤PP≤59mm Hg,PP≥60mm Hg).ANOVA was used to analyze the effect of different levels of pulse pressure on the diameter of ascending aorta.Pearson linear correlation analysis was used to analyze the correlation between the pulse pressure and ascending aorta.The prediction value of the pulse pressure for ascending aorta dilation was discussed by using Receiver Operating Characteristic(ROC)curve.Results 1.A total of 719 patients who met the standard undergoing echocardiography were included in the study,including 164 patients with ascending aorta dilatation(22.8%,76 males and 88 females)with an average age of 68.4±10.4 years,and 555 cases of normal ascending aorta(77.2%,305 males and 250 females)with an average age of 61.5±11.5 years.2.There were no significant differences in the gender,diastolic blood pressure,heart rate at admission,smoking,drinking,triglycerides,high-density lipoprotein cholesterol,blood uric acid,glycosylated hemoglobin,left ventricular ejection fraction between the two groups(P>0.05).The mean age,BMI,systolic blood pressure,pulse pressure,pulse pressure index and mean arterial pressure were much higher in the ascending aortic dilatation group than the control group(P<0.05).However,hemoglobin,total cholesterol and low-density lipoprotein cholesterol were lower than those in the ascending aortic dilatation group(P<0.05).LVED,LVES,LA,LVPW,IVS,RVOD,PA,E/E’,E/A,LVM and LVMI were larger in the ascending aortic dilatation group than in the control group(P<0.05);The ascending aortic dilatation group combined with hypertension and stroke was higher than the control group(P<0.05).3.Multivariate logistic regression analysis showed that Age,PP,LA and E/A were risk factors for ascending aortic dilatation in hospitalized patients(P<0.05).4.The results of ANOVA showed that the ascending aorta diameters were gradually increased between the three subgroups(20mm Hg≤PP≤39mm Hg,40 mm Hg≤PP≤59mm Hg,and PP≥60mm Hg)(P< 0.05).5.Pearson linear results showed there is a clear linear positive correlation between pulse pressure and ascending aortic diameter(P<0.05).6.The area under Receiver Operating Characteristic curve of PP predicted that the happening of ascending aorta dilatation in the inpatients were 0.633(P<0.05).Conclusions 1.The incidence of inpatients with ascending aorta dilation was 22.8%.2.The ascending aorta dilation of inpatients was correlated with age,BMI,PP,PPI,MAP,LAD and E/A respectively.Furthermore,hypertension and stroke were more common in the patients with ascending aorta dilation.3.PP had predictive value for the risk of ascending aorta dilatation inpatients.