Correlation Between Trimethylamine N-oxide And Non-valvular Atrial Fibrillatio

Objective: Animal studies have shown thattrimethylamine N-oxide(TMAO)is associated with the development of atrial fibrillation(AF).This study was designed to investigate the relationship between trimethylamine N-oxide and non-valvular atrial fibrillation.Methods: A total of 68 AF patients diagnosed in our hospital from August 2018 to January 2019 were enrolled in the atrial fibrillation group.There was a Control group,containing 40 patients of sinus rhythm.The plasma levels of TMAO were examined and compared among different groups.Results: The plasma level of TMAO in the atrial fibrillation group was significantly higher than that in the control group(P<0.01).Logistic regression was used to correct the confounding factors such as age,gender,cholesterol level,uric acid level,left atrial diameter,left ventricular diameter,and ejection fraction.There was still a significant increase in TMAO in the atrial fibrillation group,but there was no significant difference in the TMAO precursors such as choline,L-carnitine,glycine betaine and trimethylamine between the atrial fibrillation group and the control group.Interaction analysis of risk factors for atrial fibrillation showed that there was no multiplicative interaction between TMAO and left atrial dimension(LAD).The Spearman rank correlation analysis showed that The plasma level of TMAO was positively related to the left atrial diameter(rank correlation coefficients=0.25,P<0.05),and there was no significant correlation between interleukin-6(IL-6),interleukin-8(IL-8),high sensitivity C reactive protein(hs-CRP)and the TMAO levels in plasma.Conclusion: The plasma levels of TMAO was elevated in AF patients.The plasma levels of TMAO is a possible risk factor for AF.