Effect Of APOE Gene Polymorphism On Early Brainerebral Oxygen Saturation In Patients With TBI

Objective:To investigate the effect of apolipoprotein E gene?APOE?on early brain cerebral oxygen saturation?rScO₂?in patients after traumatic brain injury?TBI?.Methods:We retrospectively collect clinical data from 103 patients with TBI?TBI group?inthe First Affiliated Hospital of Chongqing Medical University and 50 normal subjects for control?Control group?,identify their APOE genotype by multiple quantitative fluorescent polymerase chain reaction.All patients were monitored for rScO₂ within 1³ days after injury,and all the control group member were monitored for rScO₂ under conscious and calm condition.All of these clinical and APOE genotype data were aggregated for statistical analysis.Results:TheTBI group's rScO₂ of APOE?4 carriers?54.33±4.27?%was significantly lower than that of non-?4 carriers?58.38±5.24?%?P<0.05?.But in control group the rScO₂ did not see significant differences between APOE?4 carriers?61.18±5.35?%and non-?4 carriers?62.52±6.06?%.Univariate and multivariate logistic regression analysis showed that APOE?4?P=0.003,OR=7.455,95%CI=1.95-28.47?was a risk factor for decreased rScO₂ after TBI.Conclusion:The APOE?4 may be a risk factor for decreased brain oxygen saturation in patients during acute stage after TBI.