Research Progress Of The Effects Of Metformin On Prostate Cancer

Prostate cancer is one of the malignant tumors that disturb the health of men around the world.After a period of treatment,most patients will have castration-resistant prostate cancer.At this time,they are not sensitive to conventional androgen deprivation treatment,radiotherapy or chemotherapy,and the prognosis is poor.Although there are second-line new drugs,there is no obvious advantage in prolonging the survival of patients.Studies have shown that type 2 diabetes(T2DM)is closely related to the risk of tumor development and death,and in the treatment of prostate cancer will also be accompanied by abnormal metabolic levels,affecting the prognosis of patients.Therefore,in addition to conventional treatment,it is particularly important to seek a more multi-dimensional anti-tumor method.Metformin is a classic anti-diabetic drug,and studies have found that it can exert anti-prostate cancer effects through multiple ways.Metformin has less toxic and side effects,lower cost,and multi-dimensional methods to treat prostate cancer.It has a positive significance for improving the quality of life of prostate cancer patients.This article will review the impact of metformin in prostate cancer.