The Correlation Of Visceral Fat Area And Sarcopenia In Patient With Type 2 Diabetes

Objective :This research aims to discuss the correlation of visceral fat and sarcopenia in type 2 diabetes(T2DM)patients.Methods :291 T2 DM patients who were hospitalized to the Division of Endocrinology in Chongqing Medical University No.1 Affiliated Hospital between January2016 and December 2018 were selected,among which 202 are males and89 are females.They are aged 56.9±10.3 on average.Clinical data of study objects were collected including their age,course of disease,body mass index(BMI),glycated hemoglobin(HbA1c),complications,Comorbidity and medication situation,et al.Then the HOMA-2 calculator was used to work out the HOMA2-IR.Body composition was measured by using dual energy x-ray absorptiometry(DEXA).Depending on whether or not they have sarcopenia,patients were divided into groups for a comparative statistical analysis and the multivariate logistic regression model was adopted to examine the correlation of sarcopenia and VFA.SPSS19.0software was adopted to examine the correlation of sarcopenia and relevant metric.According to the China reference standard,BMI was then divided into groups and each one of them will be again analyzed with theabove-mentioned multivariate logistic regression model.Lastly,the receiver operating characteristic(ROC)curve was adopted to analyze the predictive value of VFA for sarcopenia.Results:According to the presence or absence of sarcopenia,291 patients were divided into two groups: non-sarcopenia group(n = 233)and sarcopenia group(n = 58).The levels of BMI,systolic blood pressure,diastolic blood pressure,triglyceride(TG),VFA and Appendicular skeletal muscle index(ASMI)in sarcopenia group were lower than those in non-sarcopenia group,while the proportion of smokers was higher than that in non-sarcopenia group,the difference was statistically significant(P <0.05).Male,low BMI and high VFA were risk factors for sarcopenia(P <0.05);and that gender,BMI and VFA jointly predicted the area under the ROC curve(AUC)for sarcopenia to be 0.897.When 18.5kg/m2?BMI<24kg/m2,no apparent correlation between sarcopenia and VFA was found,but after gender and BMI were corrected,they were found to be positively correlated(OR=1.027,P=0.005);and gender,BMI and VFA jointly predicted the AUC for sarcopenia to be 0.849.When 24kg/m2?BMI<28kg/m2,VFA was positively correlated with sarcopenia(P=0.001),and after gender and BMI were corrected,such a correlation remained(OR=1.053,P=0.001);and gender,BMI and VFA jointly predicted the AUC for sarcopenia to be 0.940.Conclusion:In type 2 diabetes patients,obesity is closely correlated tosarcopenia.The combined examination of gender,BMI and VFA has a relatively high predictive value and is worthy of clinical reference.